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Diafiltration is a dilution process that involves removal or separation of components (permeable molecules like
salts
In chemistry, a salt is a chemical compound consisting of an ionic assembly of positively charged cations and negatively charged anions, which results in a compound with no net electric charge. A common example is table salt, with positively cha ...
, small
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
s,
solvent
A solvent (s) (from the Latin '' solvō'', "loosen, untie, solve") is a substance that dissolves a solute, resulting in a solution. A solvent is usually a liquid but can also be a solid, a gas, or a supercritical fluid. Water is a solvent for ...
s etc.,) of a
solution
Solution may refer to:
* Solution (chemistry), a mixture where one substance is dissolved in another
* Solution (equation), in mathematics
** Numerical solution, in numerical analysis, approximate solutions within specified error bounds
* Soluti ...
based on their
molecular size
A molecule is a group of two or more atoms held together by attractive forces known as chemical bonds; depending on context, the term may or may not include ions which satisfy this criterion. In quantum physics, organic chemistry, and bioch ...
by using micro-molecule permeable filters in order to obtain pure solution.
References
Further reading
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*
*{{cite journal , last1 = Sheth , first1 = Jignesh P. , display-authors=et al , year = 2003 , title = Nanofiltration-based diafiltration process for solvent exchange in pharmaceutical manufacturing , journal = Journal of Membrane Science , volume = 211 , issue = 2, pages = 251–261 , doi=10.1016/s0376-7388(02)00423-4
External links
Diafiltration for Desalting or Buffer ExchangeMobius Ultra/ Diafiltration Solutions
Membrane technology