A developmental signaling center is defined as a group of

cells Cell most often refers to: * Cell (biology), the functional basic unit of life Cell may also refer to: Locations * Monastic cell, a small room, hut, or cave in which a religious recluse lives, alternatively the small precursor of a monastery w ...

that release various morphogens which can determine the fates, or destined cell types, of adjacent cells. This process in turn determines what tissues the adjacent cells will form. Throughout the years, various development signaling centers have been discovered.

Spemann-Mangold organizer

In 1924, Hans Spemann and

Hilde Mangold Hilde Mangold (20 October 1898 – 4 September 1924) (née Proescholdt) was a German embryologist who was best known for her 1923 dissertation which was the foundation for her mentor, Hans Spemann's, 1935 Nobel Prize in Physiology or Medicin ...

discovered a region in the dorsal

blastopore Gastrulation is the stage in the early embryonic development of most animals, during which the blastula (a single-layered hollow sphere of cells), or in mammals the blastocyst is reorganized into a multilayered structure known as the gastrula. Be ...

lip of an amphibian embryo that induced certain neighboring cells into becoming neural tissue. This Spemann-Mangold organizer was the first time that a developmental organizer region was identified and studied.Spemann, Hans (2001). "Induction of embryonic primordia by implantation of organizers from a different species". International Journal of Developmental Biology. 45 (1): 13–38. Since then many analogous organizers have been found in other organisms. The Spemann-Mangold organizer is important to

developmental biology Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of Regeneration (biology), regeneration, asexual reproduction, metamorphosis, and the growth and di ...

because it was the first proof that particular cell populations influenced the differentiation of other cells through signaling molecules.

Nieuwkoop center

The

Nieuwkoop center In the field of developmental biology, regional differentiation is the process by which different areas are identified in the development of the early embryo. The process by which the cells become specified differs between organisms. Cell fate ...

, named after the developmental biologist Pieter Nieuwkoop, is a cluster of dorsal vegetal cells in a blastula which produce both mesoderm-inducing and dorsalizing signals. Signals from the Nieuwkoop center induce the Spemann-Mangold organizer, thus the Nieuwkoop Center is known as the organizer of the organizer. Even with the BCNE center (Blastula ''

chordin Chordin (from Greek χορδή, string, catgut) is a protein with a prominent role in dorsal–ventral patterning during early embryonic development. In humans it is encoded for by the ''CHRD'' gene. History Chordin was originally identified ...

'' and ''noggin'' expression center) removed from the blastula, the Nieuwkoop Center is able to induce formation of the Spemann-Mangold organizer. Transplant of the Nieuwkoop Center causes formation of an embryonic axis with an endodermal fate which contains dorsal

mesoderm The mesoderm is the middle layer of the three germ layers that develops during gastrulation in the very early development of the embryo of most animals. The outer layer is the ectoderm, and the inner layer is the endoderm.Langman's Medical E ...

. Due to difficulty defining definitive Nieuwkoop regions, little is known about the molecular composition of the Nieuwkoop signal. However, cells from the Nieuwkoop Center express potent mesoderm inducers as well as the secreted protein, Cerberus (CER1), which contributes to the formation of the

head A head is the part of an organism which usually includes the ears, brain, forehead, cheeks, chin, eyes, nose, and mouth, each of which aid in various sensory functions such as sight, hearing, smell, and taste. Some very simple animals may ...

, heart, and

asymmetry Asymmetry is the absence of, or a violation of, symmetry (the property of an object being invariant to a transformation, such as reflection). Symmetry is an important property of both physical and abstract systems and it may be displayed in pre ...

of internal organs. Furthermore, a

homeobox A homeobox is a DNA sequence, around 180 base pairs long, that regulates large-scale anatomical features in the early stages of embryonic development. For instance, mutations in a homeobox may change large-scale anatomical features of the full- ...

gene, ''nieuwkoid'', was named after the Nieuwkoop Center for its role in development. Nieuwkoid is expressed immediately following the mid-blastula transition to a pregastrula

embryo An embryo is an initial stage of development of a multicellular organism. In organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization of the female egg cell by the male spe ...

on the dorsal side and mis-expression of ''nieuwkoid'' was found to be sufficient for induction of secondary axes.

BCNE center

The BCNE center is the Blastula

Chordin Chordin (from Greek χορδή, string, catgut) is a protein with a prominent role in dorsal–ventral patterning during early embryonic development. In humans it is encoded for by the ''CHRD'' gene. History Chordin was originally identified ...

and Noggin Expressing center. The BCNE center is located in the dorsal region of the

animal pole In developmental biology, an embryo is divided into two hemispheres: the animal pole and the vegetal pole within a blastula. The animal pole consists of small cells that divide rapidly, in contrast with the vegetal pole below it. In some cases, the ...

. It appears after the mid-blastula stage and is triggered by the expression of beta-catenin like the

. This center is found to be distinct from the Nieuwkoop center, which secretes a different group of factors, due to expression of VegT and B1-Sox which prevents the BCNE center from extending into the vegetal pole of the blastula. The BCNE center is found to secrete several factors: chordin, noggin, Xnr3, siamois,

goosecoid Homeobox protein goosecoid (GSC) is a homeobox protein that is encoded in humans by the ''GSC'' gene. Like other homeobox proteins, goosecoid functions as a transcription factor involved in morphogenesis. In ''Xenopus'', ''GSC'' is thought to pla ...

,{{cite journal , last1=Suduo , first1=Norihiro , last2=Yamamoto , first2=Shinji , last3=Ogino , first3=Hajime , last4=Taira , first4=Masanori , title=Dynamic in vivo binding of transcription factors to cis-regulatory modules of cer and gsc in the stepwise formation of the Spemann–Mangold organizer , journal=Development , date=May 1, 2012 , volume=139 , issue=2 , pages=1651–1661 , doi=10.1242/dev.068395 , pmid=22492356, pmc=4074222 twin, Admp, and FoxA4a. This center predisposes cells in the blastula stage to become neural tissue. The cells of the BCNE region give rise to the forebrain, most of the mid-brain and hind-brain, the

notochord In anatomy, the notochord is a flexible rod which is similar in structure to the stiffer cartilage. If a species has a notochord at any stage of its life cycle (along with 4 other features), it is, by definition, a chordate. The notochord consis ...

, and the floor plate.

References

Cells Morphogens Amphibians Embryology