Depot Historic District or Depot Square Historic District may refer to:
*
Depot-Compress Historic District, Holly Springs, Mississippi,
listed on the National Register of Historic Places (NRHP) in Marshall County, Mississippi
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Meridian Depot Historic District, listed on the NRHP in Mississippi
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Depot Historic District (Marion, North Carolina),
listed on the NRHP in North Carolina
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Depot Historic District (Raleigh, North Carolina), listed on the NRHP in North Carolina
*
Depot Square Historic District (Wichita Falls, Texas),
listed on the NRHP in Wichita County, Texas
*
Depot Square Historic District (Randolph, Vermont),
listed on the NRHP in Orange County, Vermont
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