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Dens invaginatus (DI), also known as tooth within a tooth, is a rare dental malformation where there is an infolding of enamel into dentine. The prevalence of condition is 0.3 - 10%, affecting more males than females. The condition is presented in two forms, coronal and
radicular Radicular pain, or radiculitis, is pain "radiated" along the dermatome (sensory distribution) of a nerve due to inflammation or other irritation of the nerve root (radiculopathy) at its connection to the spinal column. A common form of radicul ...
, with the coronal form being more common. DI is a malformation of teeth most likely resulting from an infolding of the
dental papilla In embryology and prenatal development, the dental papilla is a condensation of ectomesenchymal cells called odontoblasts, seen in histologic sections of a developing tooth. It lies below a cellular aggregation known as the enamel organ. The ...
during
tooth development Tooth development or odontogenesis is the complex process by which teeth form from embryonic cells, grow, and erupt into the mouth. For human teeth to have a healthy oral environment, all parts of the tooth must develop during appropriate stag ...
or
invagination Invagination is the process of a surface folding in on itself to form a cavity, pouch or tube. In developmental biology, invagination is a mechanism that takes place during gastrulation. This mechanism or cell movement happens mostly in the vegetal ...
of all layers of the
enamel organ The enamel organ, also known as the dental organ, is a cellular aggregation seen in a developing tooth and it lies above the dental papilla. The enamel organ which is differentiated from the primitive oral epithelium lining the stomodeum.The enam ...
in dental papillae. Affected teeth show a deep infolding of enamel and
dentine Dentin () (American English) or dentine ( or ) (British English) ( la, substantia eburnea) is a calcified tissue of the body and, along with enamel, cementum, and pulp, is one of the four major components of teeth. It is usually covered by ena ...
starting from the foramen coecum or even the tip of the cusps and which may extend deep into the root. Teeth most affected are
maxilla The maxilla (plural: ''maxillae'' ) in vertebrates is the upper fixed (not fixed in Neopterygii) bone of the jaw formed from the fusion of two maxillary bones. In humans, the upper jaw includes the hard palate in the front of the mouth. The t ...
ry lateral
incisors Incisors (from Latin ''incidere'', "to cut") are the front teeth present in most mammals. They are located in the premaxilla above and on the mandible below. Humans have a total of eight (two on each side, top and bottom). Opossums have 18, wh ...
(80%), followed by maxillary canines (20%). Bilateral occurrence is not uncommon (25%).


Signs and symptoms

Tooth affected by this condition has a higher risk of developing caries and periradicular pathology. The thin layer of the infolding enamel could be chipped off easily, providing entrance for microorganisms into the tooth canal. This can cause abscess formation, displacement of dental structures (i.e. teeth). Preventive measures should be taken.


Cause

Cause of DI is unclear. However, there are several theories: *Infection *Trauma *Growth pressure of the dental arches during odontogenesis *Rapid proliferation of the internal enamel epithelium invades the underlying dental papilla


Diagnosis

During clinical examination, abnormally shaped tooth can be observed. Teeth with this condition can have a conical shape or deep pit on the lingual side or have an exaggerated talon cusp. Although examination may reveal a fissure on the surface of anterior tooth, radiographic examination is the way. On a periapical radiograph, the invagination lesion will appear as a radiolucent pocket. It is usually seen beneath the cingulum or incisal edge. Larger lesions can appear as fissures. A radio-opaque could be shown. Pulp may be involved and the root canal could have complex anatomy. Two periapical radiographs are often required to make sure that it is not a masked lesion. Cone beam computed tomography (CBCT) is useful in diagnosing DI. It provides clinicians a detailed 3D image and could aid treatment planning. Feasibility of root canal treatment or apical surgery or other procedures could be assessed.


Oehlers' classification

*Class I - Partial invagination. It is limited to the crown of tooth. The lesion does not extend pass the cementoenamel junction (CEJ) or the pulp. *Class II - Partial invagination. It extends beyond the crown and CEJ. Pulp may be involved but remain within the root anatomy. There is no communication of the lesion with periodontal ligament (PDL). *Class IIIa - Complete invagination. It extends through root and communicates with PDL. It usually does not involve the pulp but can cause anatomical malformation. *Class IIIb - Complete invagination. It extends through the root and communicates with PDL through apical foramen. Pulpal anatomy may not be directly involved but can cause disruption to the dental anatomy.


Histology

*No irregularities in the dentin below invagination *Strains of vital tissue or fine canals that communicates with the pulp could be found *Enamel lining irregularly structured *External and internal enamel have different structures


Management

*Preventative treatment - e.g. oral hygiene instructions, fissure sealant *Intentional replantation *Root canal treatment with mineral trioxde aggregate *Periapical surgery with retrograde filling *Extraction


References


External links

{{Developmental tooth disease Developmental tooth disorders