Deborah Beth Zamble (October 5, 1971 – July 6, 2020) was a Canadian chemist and Canada Research Chair in Biological Chemistry at the University of Toronto. Her research considered how bacteria processed metal nutrients.

Early life and education

Zamble was born in Kingston, Ontario. She attended the University of Toronto for her undergraduate studies, where she worked in the lab of the Bibudhendra Sarkar. Zamble was a graduate student at the Massachusetts Institute of Technology, where she worked with

Stephen J. Lippard Stephen James Lippard (born October 12, 1940) is the Arthur Amos Noyes Emeritus Professor of Chemistry at the Massachusetts Institute of Technology. He is considered one of the founders of bioinorganic chemistry, studying the interactions of ...

on cisplatin, an anti-cancer drug. Her research considered the role of p53 in the cellular response to the drug. Zamble was a postdoctoral fellow at the Harvard Medical School, where she worked alongside Christopher T. Walsh. At the Harvard Medical School Zamble worked on the microcin B17 synthetase.

Research and career

Zamble returned to Canada in 2001, where she was made a Canada Research Chair in Biological Chemistry. Here she investigated how bacteria process metal nutrients, with a focus on the uptake of nickel. Transition metals are essential to the structure and function of biological systems, but can be toxic if they are allowed to accumulate. To mitigate this, cells make use of metalloproteins to regulate the use of each metal. In particular, Zamble studies the bacteria '' Escherichia coli'' and '' Helicobacter pylori''.

Academic service

Zamble served on the executive board of the Royal Canadian Institute. She served on the editorial boards of the

Journal of Biological Chemistry The ''Journal of Biological Chemistry'' (''JBC'') is a weekly peer-reviewed scientific journal that was established in 1905., jbc.org Since 1925, it is published by the American Society for Biochemistry and Molecular Biology. It covers research in ...

and Metallomics. Zamble was involved with recreating the biological chemistry curriculum at the University of Toronto, leading a second year course that incorporated her enthusiasm for cooking.

Awards and honours

* 1993 University of Toronto College Science Medal * 2001 Canada Research Chair in Biological Chemistry * 2002 Premier's Research and Excellence Awards * 2007 Sloan Research Fellowship * 2009 NSERC Discovery Accelerator Research Award * 2012 Queen Elizabeth Diamond Jubilee Medal

Selected publications

* * * *

Personal life

On July 6, 2020, Zamble died of an unexpected brain haemorrhage.

References

{{DEFAULTSORT:Zamble, Deborah 1971 births 2020 deaths University of Toronto alumni Massachusetts Institute of Technology School of Science alumni Harvard Medical School faculty University of Toronto faculty Canadian women chemists 20th-century Canadian chemists 20th-century Canadian women scientists 21st-century Canadian chemists 21st-century Canadian women scientists