Deborah Ann "Debbie" Nickerson (1954 – December 24, 2021) was an American human genomics researcher. She was professor of genome sciences at the

University of Washington The University of Washington (UW, simply Washington, or informally U-Dub) is a public research university in Seattle, Washington. Founded in 1861, Washington is one of the oldest universities on the West Coast; it was established in Seattle a ...

. Nickerson founded and directed of one of the five clinical sites of the Gregor Consortium and was a major contributor to many genomics projects, including the

Human Genome Project The Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying, mapping and sequencing all of the genes of the human genome from both a ...

and the

International HapMap Project The International HapMap Project was an organization that aimed to develop a haplotype map (HapMap) of the human genome, to describe the common patterns of human genetic variation. HapMap is used to find genetic variants affecting health, disease a ...

Biography

Nickerson was born in

Mineola, New York Mineola is a village in and the county seat of Nassau County, on Long Island, in New York, United States. The population was 18,799 at the 2010 census. The name is derived from an Algonquin Chief, Miniolagamika, which means "pleasant village". ...

. She earned a bachelor's degree in biology from

Adelphi University Adelphi University is a private university in Garden City, New York. Adelphi also has centers in Manhattan, Hudson Valley, and Suffolk County. There is also a virtual, online campus for remote students. It is the oldest institution of higher ed ...

in 1974 and completed a PhD in

immunology Immunology is a branch of medicineImmunology for Medical Students, Roderick Nairn, Matthew Helbert, Mosby, 2007 and biology that covers the medical study of immune systems in humans, animals, plants and sapient species. In such we can see there ...

at the

University of Tennessee The University of Tennessee (officially The University of Tennessee, Knoxville; or UT Knoxville; UTK; or UT) is a public land-grant research university in Knoxville, Tennessee. Founded in 1794, two years before Tennessee became the 16th state, ...

in 1978. From 1978 to 1979, she pursued a postdoctoral fellowship in infectious diseases at the

University of Kentucky The University of Kentucky (UK, UKY, or U of K) is a Public University, public Land-grant University, land-grant research university in Lexington, Kentucky. Founded in 1865 by John Bryan Bowman as the Agricultural and Mechanical College of Kentu ...

. She worked at the

University of South Florida The University of South Florida (USF) is a public research university with its main campus located in Tampa, Florida, and other campuses in St. Petersburg and Sarasota. It is one of 12 members of the State University System of Florida. USF is ...

and the

California Institute of Technology The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasional ...

with

Leroy Hood Leroy "Lee" Edward Hood (born October 10, 1938) is an American biologist who has served on the faculties at the California Institute of Technology (Caltech) and the University of Washington. Hood has developed ground-breaking scientific instrum ...

, before being recruited by Hood to the University of Washington in 1992. Nickerson was a founding member of the University of Washington Department of Genome Sciences in 2001. Nickerson died of abdominal cancer in

Seattle, Washington Seattle ( ) is a port, seaport city on the West Coast of the United States. It is the county seat, seat of King County, Washington, King County, Washington (state), Washington. With a 2020 population of 737,015, it is the largest city in bo ...

on December 24, 2021.

Work

Nickerson's work focused on the application of genomic technologies to understand genetic variation underlying human health and disease, and advanced the idea of cataloging human genomic diversity to improve genetic discoveries and diagnoses. Notable work by Nickerson's group included illuminating of the

pharmacogenomics Pharmacogenomics is the study of the role of the genome in drug response. Its name ('' pharmaco-'' + ''genomics'') reflects its combining of pharmacology and genomics. Pharmacogenomics analyzes how the genetic makeup of an individual affects the ...

warfarin Warfarin, sold under the brand name Coumadin among others, is a medication that is used as an anticoagulant (blood thinner). It is commonly used to prevent blood clots such as deep vein thrombosis and pulmonary embolism, and to prevent strok ...

dosing, and producing early catalogs of normal human genomic variation. Using

exome sequencing Exome sequencing, also known as whole exome sequencing (WES), is a genomic technique for sequencing all of the protein-coding regions of genes in a genome (known as the exome). It consists of two steps: the first step is to select only the subse ...

, Nickerson also identified the gene for

Miller syndrome Miller syndrome, also known as Genée–Wiedemann syndrome, Wildervanck–Smith syndrome or postaxial acrofacial dystosis, is an extremely rare genetic condition that manifests as craniofacial, limb and eye deformities. It is caused by a mutation ...

with her colleagues Michael Bamshad and

Jay Shendure Jay Shendure is an American scientist and human geneticist at the University of Washington. He is a professor in the Department of Genome Sciences at the University of Washington School of Medicine and an Affiliate Investigator in the Human Biolo ...

. The study was the first to illustrate the practicality of using genomic technologies to identify the genes underlying rare Mendelian disorders by studying a small number of unrelated affected individuals.

Selected publications

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References

1954 births 2021 deaths University of Washington faculty University of South Florida faculty California Institute of Technology faculty Adelphi University alumni University of Tennessee alumni American geneticists American women geneticists People from Mineola, New York {{US-biologist-stub