''Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus'' (Latin, 'An Anatomical Exercise on the Motion of the Heart and Blood in Living Beings'), commonly called ''De Motu Cordis'', is the best-known work of the physician
William Harvey
William Harvey (1 April 1578 – 3 June 1657) was an English physician who made influential contributions in anatomy and physiology. He was the first known physician to describe completely, and in detail, the systemic circulation and proper ...
, which was first published in 1628 and established the
circulation of blood
The blood circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the entire body of a human or other vertebrate. It includes the cardiovascular system, or vascular system, tha ...
throughout the body. It is a landmark in the history of
physiology
Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...
, with Harvey combining observations, experiments, measurements, and hypotheses in an extraordinary fashion to arrive at his doctrine. His work is a model of its kind and had an immediate and far-reaching influence on Harvey's contemporaries;
Thomas Hobbes
Thomas Hobbes ( ; 5/15 April 1588 – 4/14 December 1679) was an English philosopher, considered to be one of the founders of modern political philosophy. Hobbes is best known for his 1651 book ''Leviathan'', in which he expounds an influent ...
said that Harvey was the only modern author whose doctrines were taught in his lifetime.
In ''De motu cordis'', Harvey investigated the effect of
ligatures on blood flow. The book also argued that blood was pumped around the body in a "double circulation", where after being returned to the heart, it is recirculated in a closed system to the lungs and back to the heart, where it is returned to the main circulation.
Synopsis
This work is a substantial contribution to cardiac physiology, for it introduces into biology the doctrine of circulation of the blood in the seventeenth century. Opposed and obliging work heralding Harvey's discovery go back to the thirteenth century, when the pulmonary circulation and gas exchange was proposed by Ibn
Al-Nafis. Both long since proven theories are incomplete when studied separately but together form core knowledge of present-day
cardiology
Cardiology () is a branch of medicine that deals with disorders of the heart and the cardiovascular system. The field includes medical diagnosis and treatment of congenital heart defects, coronary artery disease, heart failure, valvular heart d ...
. In 1553,
Michael Servetus
Michael Servetus (; es, Miguel Serveto as real name; french: Michel Servet; also known as ''Miguel Servet'', ''Miguel de Villanueva'', ''Revés'', or ''Michel de Villeneuve''; 29 September 1509 or 1511 – 27 October 1553) was a Spanish th ...
said that blood flows from the heart to the lungs, and that it there mixes with air to form the arterial blood which flows back to the heart. Between 1570 and 1590,
Cesalpino
Andrea Cesalpino ( Latinized as Andreas Cæsalpinus) (6 June 1524 – 23 February 1603) was a Florentine physician, philosopher and botanist.
In his works he classified plants according to their fruits and seeds, rather than alphabetically ...
suggested, in a controversy with
Galenists, that the movement of blood was more like a circulation than an oscillation; but this view lacks clarity. In 1603,
Hieronymus Fabricius
Girolamo Fabrici d'Acquapendente, also known as Girolamo Fabrizio or Hieronymus Fabricius (20 May 1533 – 21 May 1619), was a pioneering anatomist and surgeon known in medical science as "The Father of Embryology."
Life and accomplishments ...
ab
Acquapendente Acquapendente is a city and ''comune'' in the province of Viterbo, in Lazio (Italy). Acquapendente is a centre for the agricultural production of vegetables and wine, and has a tradition of pottery craftsmanship.
History
The area of modern Acquapen ...
published a work clearly describing the
valves
A valve is a device or natural object that regulates, directs or controls the flow of a fluid (gases, liquids, fluidized solids, or slurries) by opening, closing, or partially obstructing various passageways. Valves are technically fittings ...
in the
veins
Veins are blood vessels in humans and most other animals that carry blood towards the heart. Most veins carry deoxygenated blood from the tissues back to the heart; exceptions are the pulmonary and umbilical veins, both of which carry oxygenated b ...
and showing that they hinder the flow of blood away from the
heart
The heart is a muscular organ in most animals. This organ pumps blood through the blood vessels of the circulatory system. The pumped blood carries oxygen and nutrients to the body, while carrying metabolic waste such as carbon dioxide t ...
. From 1597 to 1602, Harvey studied arts and medicine at
Padua
Padua ( ; it, Padova ; vec, Pàdova) is a city and ''comune'' in Veneto, northern Italy. Padua is on the river Bacchiglione, west of Venice. It is the capital of the province of Padua. It is also the economic and communications hub of the ...
, and made a careful study of the heart and the movement of blood. By 1616, he was presenting in lectures his case for the
circulation of the blood
The blood circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the entire body of a human or other vertebrate. It includes the cardiovascular system, or vascular system, tha ...
, but it was not until 1628 that he published it in his classic work, ''De Motu Cordis et Sanguinis''. This book is important both for the discovery of the complete circulation and for the experimental, quantitive and mechanistic methodology which Harvey introduced. He looked upon the heart, not as a mystical seat of the spirit and faculties, but as a
pump
A pump is a device that moves fluids (liquids or gases), or sometimes slurries, by mechanical action, typically converted from electrical energy into hydraulic energy. Pumps can be classified into three major groups according to the method they u ...
analyzable along mechanical lines. He also measured the amount of blood which it sent out to the body. He observed that with each beat two ounces of blood leave the heart; so that with 72 heart beats per minute, the heart throws into the system 540 pounds of blood every hour. Where could all this blood come from? The answer seems to be that it is the same blood that is always returning. Moreover, the one-way valves in the heart, like those in the veins, indicate that, following the
pulmonary circulation
The pulmonary circulation is a division of the circulatory system in all vertebrates. The circuit begins with deoxygenated blood returned from the body to the right atrium of the heart where it is pumped out from the right ventricle to the lungs. ...
, the blood goes out to all parts of the body through the
arteries
An artery (plural arteries) () is a blood vessel in humans and most animals that takes blood away from the heart to one or more parts of the body (tissues, lungs, brain etc.). Most arteries carry oxygenated blood; the two exceptions are the pul ...
and returns by way of the veins. The blood thus makes a complete
closed circuit
Closed circuit can refer to:
*Closed-circuit television
*Closed-circuit radio
*Rebreather – breathing sets
* ''Closed Circuit'' (1978 film), a 1978 Italian film
* ''Closed Circuit'' (2013 film), a 2013 British thriller film
*An electric circuit
...
. As Harvey expressed it, "There must be a motion, as it were, in a circle." There was, however, one stage in the circulation which Harvey was not able to see - that in which the veins and arteries lose themselves by subdivision into the tiny capillary vessels. It was in 1660, three years after Harvey's death, that
Marcello Malpighi
Marcello Malpighi (10 March 1628 – 30 November 1694) was an Italian biologist and physician, who is referred to as the "Founder of microscopical anatomy, histology & Father of physiology and embryology". Malpighi's name is borne by several phy ...
saw the blood moving in the
capillaries
A capillary is a small blood vessel from 5 to 10 micrometres (μm) in diameter. Capillaries are composed of only the tunica intima, consisting of a thin wall of simple squamous endothelial cells. They are the smallest blood vessels in the body: ...
of a
frog
A frog is any member of a diverse and largely Carnivore, carnivorous group of short-bodied, tailless amphibians composing the order (biology), order Anura (ανοὐρά, literally ''without tail'' in Ancient Greek). The oldest fossil "proto-f ...
's lung, and thus supplied the missing link in Harvey's proof of the circulation of the blood.
External links
English translation of the book by Robert Willisat
Fordham University
Fordham University () is a Private university, private Jesuit universities, Jesuit research university in New York City. Established in 1841 and named after the Fordham, Bronx, Fordham neighborhood of the The Bronx, Bronx in which its origina ...
English translation of the book by Robert Willisas it appeared in the
Harvard Classics
''The Harvard Classics'', originally marketed as Dr. Eliot's Five-Foot Shelf of Books, is a 50-volume series of classic works of world literature, important speeches, and historical documents compiled and edited by Harvard University President Ch ...
''Exercitatio Anatomica de Motu Cordis et Sanguinis ''1628. From
Rare Book Room
Rare Book Room is an educational website for the repository of digitally scanned rare books made freely available to the public.
Story
Starting around 1996 the California-based company Octavo began scanning rare and important books from librarie ...
. Scanned first edition.
*
{{History of biology
1628 books
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1628 in science
17th-century Latin books