David R. Soll

David R. Soll (born April 29, 1942) is a Professor of Biology at the University of Iowa. He is best known for the motion analysis of living cells, the discovery of ''Candida albicans'' phenotypic switching and monoclonal antibody technology. He directed the Developmental Studies Hybridoma Bank from 1995-2021, and the WM Keck Dynamic Image Analysis Facility from 1985-2021. He is a Fellow of both the American Academy of Microbiology and the American Association for the Advancement of Science since 2006. He has published over 400 articles in various fields of biomedicine, and has received more than 78 grants and contracts, founded four companies, and is active on several editorial boards for major scientific publications.

Background

Soll was born in South Philadelphia, Pennsylvania and graduated from Central High School for Boys in 1959 with a BA and has been inducted into the Central High School Hall of Fame (2018). He attended the University of Wisconsin from 1960 to 1969, receiving a BA, MS and PhD. He served as a post-doctoral fellow and taught Introductory Biology at Brandeis University. In 1972 he joined the Department of Biology at the University of Iowa as an Assistant Professor. In 1976 he became an Associate Professor and in 1982 a Full Professor. In 1989 he was awarded the Roy J. and Lucille Carver/Emil Witschi Professorship of the Biological Sciences, and in 1989 also became a Full Professor of Dentistry. In 2005, he was elected a Fellow of the American Association for the Advancement of Science (AAAS) and in 2006 a Fellow of the American Academy of Microbiology. In 2009 he was awarded the Lucille K. George Medal from the International Society for Human and Animal Mycology, and in 2013 he was awarded the Rhoda Benham Medal from the Medical Mycological Society of the Americas. David Soll was married for 30 years to Michele Morice (1953-2010) and is currently married to Dr. Melinda A. Weinstein, a literary and art historian. He has three children, Jacob Soll, Samantha Soll and Benjamin Soll.

Career

From 1965 to 1970, he worked on the germination of ''Blastoclandiella emersonii'' under the mentorship of David Sonneborn and discovered that complex differentiations can be preprogrammed and occur without RNA or protein synthesis. From 1972 to 1978, he and colleagues worked on the "accumulation and erasure of morphogenetics information" in ''Dictyostelium discoideum''. In 1979, he formulated the first model and conditional methods to analyze timer pathways in developing systems. From 1977 to 1984, he developed pH-regulated dimorphism and applied it to study the regulation of the bud-hypha transition in ''Candida albicans'' In 1985 to 1987, he and colleagues discovered the first high frequency switching system in the pathogenic yeast ''Candida albicans''. Next to this phenotypic, morphological switching system he and his co-workers also discovered the epigenetic, phenotypic white-to-opaque switching system. In 1989, he and Dr. E Voss finished and licensed the Dynamic Motion Analyses System (DMS), to Motion Analyses Corporation of Santa Rosa, CA. In 1997, Soll and Voss obtained the patent for DIAS, the next generation of DMS. In 1992 Soll founded the company Solltech, Inc., a computer software and hardware development company to develop and distribute DIAS. From 1987 to 1995, he and co-workers developed the first DNA fingerprinting probes for studying the population structure of infectious fungi, and in 1995 received a patent for the software DENDRON, which analyzed DNA fingerprints. In 1995, Soll formed the company Caviforce Technologies to develop a method of using ultrasound for seed germination. From 1995 to 2004, he and colleagues developed the first 3D Dynamic Image Analysis System (3D-DIAS) for cells and embryos, describing how embryos form and amoeboid cells crawl. Ultrasound Solutions Inc., was formed in 1999 to develop the technology to use ultrasound in waste management. In 2003 Soll founded the company Solltechnologies Inc., to sell DIAS and Dendron software. From 2005 to present, he and colleagues discovered that ''Candida albicans'' forms a "pathogenic" biofilm and a "sexual" biofilm, depending on the configuration of the mating type locus and identified the alternative pathways regulating each biofilm. From 2011 to present, he and colleagues developed a 4D model for reconstructing and motion analyzing cancer cells and tumorigenesis.

Current Work

Soll continues to publish on 1) the role of mating and switching in the pathogenesis of Candida albicans, 2) cell motility and the cytoskeleton, 3) advanced monoclonal antibody technology and 4) methods for suppressing tumorigenesis in cancer patients using monoclonal antibodies. He is currently adapting the software programs DIAS and DENDRON to study digitized fine art paintings.

References

{{DEFAULTSORT:Soll, David R.
1942 births
Living people
Educators from Philadelphia
Central High School (Philadelphia) alumni
University of Wisconsin–Madison alumni
University of Iowa faculty
21st-century American biologists
Fellows of the American Academy of Microbiology