Sir David Philip Lane (born 1 July 1952) is a British immunologist,

molecular biologist Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...

and cancer researcher. He is currently working in the Department of Microbiology, Tumor and Cell Biology at the Karolinska Institute and i
Chairman of Chugai Pharmabody
He is best known for the discovery of p53, one of the most important tumour suppressor genes.

Education

Lane attended

The John Fisher School The John Fisher School is a Roman Catholic voluntary-aided boys' faith school based at Peaks Hill, Purley, Croydon, Surrey, England. The school is located in and funded by the London Borough of Sutton. It occupies the former site of the 19th-ce ...

in Purley, South London. He completed his undergraduate and postgraduate degrees at University College, London where he studied auto-immunity under the supervision of

Avrion Mitchison (Nicholas) Avrion Mitchison (born 5 May 1928) is a British zoologist and immunologist. Biography Mitchison was born in 1928, the son of the Labour politician Dick Mitchison (Baron Mitchison of Carradale in the County of Argyll, who died 197 ...

Career and research

Lane carried out postdoctoral research first at the Imperial Cancer Research Fund (ICRF) in London with

Lionel Crawford Dr Lionel Vivian Crawford (born 1932) is a British cancer expert and virologist. He was educated at Rendcomb College between 1941 and 1950 before being called up for National Service. After demobilization in 1952 he studied at Emmanuel College ...

and then at the Cold Spring Harbor Laboratory in New York with

Joseph Sambrook Joseph Frank Sambrook (1 March 1939 – 14 June 2019) was a British molecular biologist known for his studies of DNA oncoviruses and the molecular biology of normal and cancerous cells. Education and early career Sambrook was educated at the ...

. On returning to the UK, Lane set up his own laboratory with

Cancer Research Campaign Cancer Research UK (CRUK) is the world's largest independent cancer research organization. It is registered as a charity in the United Kingdom and Isle of Man, and was formed on 4 February 2002 by the merger of The Cancer Research Campaign and t ...

(CRC) funding at Imperial College, London, then moving to the ICRF laboratories at Clare Hall before moving in 1990 to the University of Dundee to help establish the CRC laboratories there. He has played an active part in UK science, sitting at various times on the scientific committee of the CRC, the Cell Board of the MRC, and on the council of the ICRF. He is dedicated to the successful translation of research for patient benefit and participated in the early discussions around the scientific benefits of the merger of ICRF and CRC, before serving as chief scientist to their successor, Cancer Research UK, until 2010. Lane founded the Dundee-based Biotechnology company, Cyclacel Ltd and was the chief scientific officer from 1996 to 2004. From 2004 to 2007, he was the executive director of the Institute of Molecular & Cell Biology (IMCB) in Singapore. Sir David was chief scientist of Singapore's Agency for Science, Technology and Research (A*STAR, Singapore). He is also professor of tumour suppressor biology at the Department of Microbiology, Tumor and Cell Biology at the Karolinska Institute, where he is headin
a research group
Lane has published more than 350 research articles that have bee
cited over 100,000 times
and is internationally recognised for his original discovery of the

p53 protein p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often s ...

SV40 T antigen complex and for his many subsequent contributions to the p53 field. The p53 gene is the most frequently altered gene in human cancer with more than half of all cancers having mutant p53. He is co-author with Ed Harlow of the most successful practical guide to the use of immunochemical methods. The "Antibodies" manual has sold over 40,000 copies.

Awards and honours

Lane is a member of the European Molecular Biology Organization (EMBO), and in 1996 was elected a Fellow of the Royal Society, the UK's premier Academy. He is also a Fellow of the Royal Society of Edinburgh, the Royal College of Pathologists, the Royal College of Surgeons of Edinburgh and a founder member of the Academy of Medical Sciences. He has won many international prizes for his work including the

Joseph Steiner Prize Joseph is a common male given name, derived from the Hebrew Yosef (יוֹסֵף). "Joseph" is used, along with "Josef", mostly in English, French and partially German languages. This spelling is also found as a variant in the languages of the mo ...

, the Meyenburg Prize (1995), the

Yvette Mayent Prize Yvette is female given name, the French feminine form of Yves, which means yew or archer in some cases. Name days *Czech Republic: ''7 June'' *Hungary: ''13 January'', ''6 May'' and ''29 June'' *Poland: ''13 January'' *Slovakia: ''27 May'' * ...

, the

Paul Ehrlich Prize The Paul Ehrlich and Ludwig Darmstaedter Prize is an annual award bestowed by the since 1952 for investigations in medicine. It carries a prize money of 120,000 Euro. The prize awarding ceremony is traditionally held on March 14, the birthday of N ...

and the Cancer Research UK Lifetime Achievement Prize (2012). He has been awarded honorary degrees from the Universities of Toulouse, Birmingham, Aberdeen, Stirling, Abertay, Brno and Nottingham. He has also been recognized for his business acumen with the award of Emerging Entrepreneur of the year. On 29 September 2016

opened the Sir David Lane building."In the Right Lane, Callum Lawlor, The John Fisher School"
''This is local London.'' 2016-10-23. Retrieved 2018-04-04 He was knighted for his contribution to cancer research in the New Year honours list in January 2000.

References

External links

Homepage at the University of Dundee
{{DEFAULTSORT:Lane, David 1952 births Living people Alumni of University College London British cancer researchers Knights Bachelor Fellows of the Royal Society Fellows of the Royal Society of Edinburgh Academics of the University of Dundee Fellows of the Academy of Medical Sciences (United Kingdom) Fellows of the AACR Academy People educated at The John Fisher School