Datumetine is a
tropane alkaloid
Tropane alkaloids are a class of bicyclic .2.1alkaloids and secondary metabolites that contain a tropane ring in their chemical structure. Tropane alkaloids occur naturally in many members of the plant family Solanaceae. Certain tropane alkal ...
found in leaves of ''
Datura metel
''Datura metel'' is a shrub-like annual (zone 5–7) or short-lived, shrubby perennial (zone 8–10), commonly known in Europe as Indian thornapple, Hindu Datura, or metel and in the United States as devil's trumpet or angel's trumpet. ''Datura ...
''.
It is said to
modulate NMDA receptor
The ''N''-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel found in neurons. The NMDA receptor is one of three types of ionotropic glutamate receptors, the other two being AMPA rece ...
and thus causes memory loss.
It also causes epileptic seizures in mice.
studies suggest that it fits on both
allosteric
In biochemistry, allosteric regulation (or allosteric control) is the regulation of an enzyme by binding an effector molecule at a site other than the enzyme's active site.
The site to which the effector binds is termed the ''allosteric site ...
and
orthosteric sites of NMDA receptor.
It acts together with other
anticholinergic
Anticholinergics (anticholinergic agents) are substances that block the action of the neurotransmitter called acetylcholine (ACh) at synapses in the central and peripheral nervous system.
These agents inhibit the parasympathetic nervous system ...
tropane alkaloids of datura to cause amnesia.
See also
* ''
Datura ferox
''Datura ferox'', commonly known as long spined thorn apple and fierce thornapple, as well as Angel's-trumpets, is a species of ''Datura''. Like all such species, every part of the plant contains deadly toxins that can kill animals (including hum ...
''
References
Tropane alkaloids
Tropane alkaloids found in Solanaceae
Benzoic acids
Methoxy compounds
Phenyl compounds
NMDA receptor modulators
{{Alkaloid-stub