Daniel Mansuy is a French researcher and
chemist
A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties. Chemists carefully describe ...
born in 1945 in
Châteauroux
Châteauroux (; ; oc, Chasteurós) is the capital city of the French department of Indre, central France and the second-largest town in the province of Berry, after Bourges. Its residents are called ''Castelroussins'' () in French.
Climate
Ch ...
(Indre), a member of the
French Academy of Sciences
The French Academy of Sciences (French: ''Académie des sciences'') is a learned society, founded in 1666 by Louis XIV at the suggestion of Jean-Baptiste Colbert, to encourage and protect the spirit of French scientific research. It was at th ...
.
Biography
Daniel Mansuy graduated from the
École nationale supérieure de chimie de Paris (now Chimie Paris Tech) in 1967 and obtained a
doctorate
A doctorate (from Latin ''docere'', "to teach"), doctor's degree (from Latin ''doctor'', "teacher"), or doctoral degree is an academic degree awarded by universities and some other educational institutions, derived from the ancient formalism '' ...
in science from the
Université Pierre-et-Marie-Curie in 1970 under the supervision of
Marc Julia.
[Page de Daniel Mansuy sur le site du ''Laboratoire de Chimie & Biochimie Pharmacologiques et Toxicologiques''](_blank)
/ref> He then joined the CNRS
The French National Centre for Scientific Research (french: link=no, Centre national de la recherche scientifique, CNRS) is the French state research organisation and is the largest fundamental science agency in Europe.
In 2016, it employed 31,63 ...
as a research manager and then director of research in 1992. He was co-founder in 1984 and director (1984-1996 and 1999-2005) of the Laboratory of Pharmaceutical and Toxicological Chemistry and Biochemistry at Paris Descartes University
Paris Descartes University (french: Université Paris 5 René Descartes, links=no), also known as Paris V, was a French public university located in Paris. It was one of the inheritors of the historic University of Paris, which was split into 13 ...
. He is currently Director of Research Emeritus Outstanding Class.
Scientific work
Daniel Mansuy is particularly interested in phenomena at the interface between chemistry and biology
Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditar ...
, and in particular in the chemistry and pharmacochemistry of cytochromes P450. His work has led to the discovery of a new class of carbene and nitrene iron
Iron () is a chemical element with symbol Fe (from la, ferrum) and atomic number 26. It is a metal that belongs to the first transition series and group 8 of the periodic table. It is, by mass, the most common element on Earth, right in ...
complexes and of one of the first catalytic systems of nitrene transfer to alkanes and alkenes. He has also developed new catalysts
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recycl ...
for the oxidation of alkane
In organic chemistry
Organic chemistry is a subdiscipline within chemistry involving the science, scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms tha ...
s, alkene
In organic chemistry, an alkene is a hydrocarbon containing a carbon–carbon double bond.
Alkene is often used as synonym of olefin, that is, any hydrocarbon containing one or more double bonds.H. Stephen Stoker (2015): General, Organic, an ...
s and aromatics
Aromatic compounds, also known as "mono- and polycyclic aromatic hydrocarbons", are organic compounds containing one or more aromatic rings. The parent member of aromatic compounds is benzene. The word "aromatic" originates from the past grouping ...
, used to predict drug metabolism
Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run c ...
and in the field of pollution
Pollution is the introduction of contaminants into the natural environment that cause adverse change. Pollution can take the form of any substance (solid, liquid, or gas) or energy (such as radioactivity, heat, sound, or light). Pollutants, the ...
control. In the field of molecular toxicology, his work has led to understand the molecular origin of drug interactions involving macrolide
The Macrolides are a class of natural products that consist of a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered. M ...
antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy, ...
s such as TAO and of immunoallergic drug hepatitis
Hepatitis is inflammation of the liver parenchyma, liver tissue. Some people or animals with hepatitis have no symptoms, whereas others develop yellow discoloration of the skin and whites of the eyes (jaundice), Anorexia (symptom), poor appetite ...
due to tienilic acid.
He is the author or co-author of more than 400 scientific publications.
Awards and honours
* CNRS Silver Medal
The CNRS Silver Medal is a scientific award given every year to about fifteen researchers by the French National Centre for Scientific Research (CNRS). It is awarded to a researcher for "the originality, quality and importance of their work, re ...
(1982)
*FEBS Award 1983
* Atochem Raymond Berr Award (1990)
* Elected Correspondent of the French Academy of Sciences (1993)Ordre national du Mérite
The Ordre national du Mérite (; en, National Order of Merit) is a French order of merit with membership awarded by the President of the French Republic, founded on 3 December 1963 by President Charles de Gaulle. The reason for the order's es ...
References
{{DEFAULTSORT:Mansuy, Daniel
1945 births
Living people