Dan Larhammar
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Dan Larhammar (born April 1, 1956) is a Swedish academic professor in molecular
cell biology Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living and ...
at
Uppsala University Uppsala University ( sv, Uppsala universitet) is a public university, public research university in Uppsala, Sweden. Founded in 1477, it is the List of universities in Sweden, oldest university in Sweden and the Nordic countries still in opera ...
. His research concerns evolution, neurobiology, endocrinology and pharmacology. As of 2021 Larhammar leads a research team at Uppsala that studies receptors for brain neurotransmitters and uses
zebrafish The zebrafish (''Danio rerio'') is a freshwater fish belonging to the minnow family ( Cyprinidae) of the order Cypriniformes. Native to South Asia, it is a popular aquarium fish, frequently sold under the trade name zebra danio (and thus often ...
as a model species to investigate the localization and functions of memory proteins. Larhammar also serves as President of the
Royal Swedish Academy of Sciences The Royal Swedish Academy of Sciences ( sv, Kungliga Vetenskapsakademien) is one of the Swedish Royal Academies, royal academies of Sweden. Founded on 2 June 1739, it is an independent, non-governmental scientific organization that takes special ...
since 2018 and is a skepticism activist.


Education

Larhammar received his pharmacist degree in 1980 and a PhD in medical science at
Uppsala University Uppsala University ( sv, Uppsala universitet) is a public university, public research university in Uppsala, Sweden. Founded in 1477, it is the List of universities in Sweden, oldest university in Sweden and the Nordic countries still in opera ...
in 1984.


Career

Since 1994 Larhammar has been a professor of molecular biology at Uppsala University where he has supervised 22 students to a PhD degree. His research focuses on three lines of research: clarifying the evolution of the mechanisms for long-term memory, resolving the evolution important gene families in vertebrates, and investigating
G protein-coupled receptor G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...
s which make them bind to and respond to, or reject, certain
ligands In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex. The bonding with the metal generally involves formal donation of one or more of the ligand's electro ...
. Using zebrafish, Larhammar explores the localization and functions of the memory proteins. His team works on discovering at what point new functions rose and how they have changed over the course of evolution, especially in gene families that include
neuropeptides Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons. Neuropeptides typically bind to G protein-coupled receptors (GPCRs) to modulate neural activity and other tissues like the ...
, G-protein-coupled receptors,
ion channel Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of io ...
s, and genes involved in vision. In 2007, Larhammar was elected member of the
Royal Swedish Academy of Sciences The Royal Swedish Academy of Sciences ( sv, Kungliga Vetenskapsakademien) is one of the Swedish Royal Academies, royal academies of Sweden. Founded on 2 June 1739, it is an independent, non-governmental scientific organization that takes special ...
and serves as its president since 2018. He was the chairman of the Swedish Skeptics' Association 1998–2004. As a critic of
pseudoscience Pseudoscience consists of statements, beliefs, or practices that claim to be both scientific and factual but are incompatible with the scientific method. Pseudoscience is often characterized by contradictory, exaggerated or falsifiability, unfa ...
, he has mostly examined
alternative medicine Alternative medicine is any practice that aims to achieve the healing effects of medicine despite lacking biological plausibility, testability, repeatability, or evidence from clinical trials. Complementary medicine (CM), complementary and alt ...
and
creationism Creationism is the religious belief that nature, and aspects such as the universe, Earth, life, and humans, originated with supernatural acts of divine creation. Gunn 2004, p. 9, "The ''Concise Oxford Dictionary'' says that creationism is 't ...
.


Activism

Larhammar is a skeptic of pseudoscience, creationism and alternative medicine. In an issue of ''Skeptical Inquirer'' Larhammar addresses an article written by a creationist, Dmitrii A. Kuznetsov, attempting to disprove evolution by isolating
mRNA In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of Protein biosynthesis, synthesizing a protein. mRNA is ...
from three species of
voles Voles are small rodents that are relatives of lemmings and hamsters, but with a stouter body; a longer, hairy tail; a slightly rounder head; smaller eyes and ears; and differently formed molars (high-crowned with angular cusps instead of low-c ...
. Each vole species was found to have a substance that blocked the production of protein from the other two species' mRNA production of protein, but did not block its own species' mRNA. The inhibiting substance however did not prevent protein synthesis of two distantly related mRNAs. Larhammar looked into the study and found that several sources and journals listed in the study did not exist. Larhammar also criticizes the lack of qualitative data of the experiments, relying only on quantitative results. In an interview with Linda Givetash, Larhammar criticizes the herbal remedies for
COVID-19 Coronavirus disease 2019 (COVID-19) is a contagious disease caused by a virus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first known case was COVID-19 pandemic in Hubei, identified in Wuhan, China, in December ...
pushed by China. Larhammar addresses studies from Chinese and Japanese journals that support herbal remedies do not have adequate sample sizes, use vague terms and nonpharmacological concepts, or to be testing too many combinations of herbs to parse out their specific effects. During another interview at the European Academics Science Advisory Council, Larhammar discusses the harm alternative medicine can have, especially during a pandemic. He states people may rely on non-working methods in lieu of seeking professional help with methods backed by evidence. Furthermore, these people will think they are protected, in turn causing them to take greater risks exposing themselves and others to the virus. This, Larhammar says, can lead those people into false beliefs that the disease is not as severe as it really is. Larhammar was during 2020-2021 the chairperson of a committee of experts appointed by ALLEA,the European Federation of Academies of Sciences and Humanitie

that wrote a discussion paper with the title "Fact or Fake? Tackling Science Disinformation" . The report summarizes research on the spread of disinformation, especially the psychology behind it. Focusing on disinformation on climate change, vaccines and covid-19, the report describe strategies to limit the harm, especially careful checking of facts and sources, and recommends coordination of efforts to achieve this.


Awards

Larhammar has also appeared as a critic of
religion Religion is usually defined as a social- cultural system of designated behaviors and practices, morals, beliefs, worldviews, texts, sanctified places, prophecies, ethics, or organizations, that generally relates humanity to supernatural, ...
, and in 2000 he was the first receiver of the Hedenius Award given by the
Swedish Humanist Association Humanists Sweden ( sv, Humanisterna) is the largest humanist/ rationalist organisation in Sweden with about 4,500 members. It is a member organisation of Humanists International (HI) and the European Humanist Federation (EHF). Humanists Swed ...
with the motivation that he has "with sharpness and pathos defended scientific knowledge, rationalism and humanism". Larhammar together with Prof. Leif Andersso

was awarded the Linnaeus Prize in Zoology 2004 by the
Royal Physiographic Society in Lund The Royal Physiographic Society in Lund ( sv, Kungliga Fysiografiska Sällskapet i Lund), is one of the Royal Academies in Sweden. It was founded in Lund, on December 2, 1772, and received a Royal Charter by Gustav III, on March 6, 1778.
. In 2016 Larhammar received the Pharmacist of the Year award, given by Pharmacists of Sweden. The award is given to a pharmacist active in
Sweden Sweden, formally the Kingdom of Sweden,The United Nations Group of Experts on Geographical Names states that the country's formal name is the Kingdom of SwedenUNGEGN World Geographical Names, Sweden./ref> is a Nordic country located on ...
who, through his or her work within practical pharmacy, has contributed to strengthen, develop or consolidate the role of pharmacy within society. On January 28, 2022, Larhammar was awarded His Majesty the King's 12th size gold medal worn around the neck on the Order of the Seraphim ribbon "for meritorious contributions within the Swedish academic system." November 3rd 2022 the Government of Japan announced the foreign recipients of the 2022 Autumn Conferment of Japanese Decoration. Larhammar was awarded
The Order of the Rising Sun The is a Japanese order, established in 1875 by Emperor Meiji. The Order was the first national decoration awarded by the Japanese government, created on 10 April 1875 by decree of the Council of State. The badge features rays of sunlight ...
, Gold and Silver Star for his "contribution to the promotion of academic exchanges and mutual understanding between Japan and Sweden."


Gallery


References


External links


Dan Larhammar's researchDan Larhammar's profile at Uphttps://en.wikipedia.org/w/index.php?title=Dan_Larhammar&action=submitpsala University
{{DEFAULTSORT:Larhammar, Dan Swedish skeptics Swedish atheists Uppsala University alumni Uppsala University faculty 1956 births Living people