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Dagmar Ringe (born February 20, 1942) is an American biochemist, educator, and researcher. She is the Harold and Bernice Davis Professor in Aging and Neurodegenerative Disease at
Brandeis University , mottoeng = "Truth even unto its innermost parts" , established = , type = Private research university , accreditation = NECHE , president = Ronald D. Liebowitz , pro ...
in
Waltham, Massachusetts Waltham ( ) is a city in Middlesex County, Massachusetts, United States, and was an early center for the labor movement as well as a major contributor to the American Industrial Revolution. The original home of the Boston Manufacturing Company, th ...
and holds appointments in the departments of Chemistry and Biochemistry.


Education

Ringe received the Bachelor's degree in Chemistry from
Barnard College Barnard College of Columbia University is a private women's liberal arts college in the borough of Manhattan in New York City. It was founded in 1889 by a group of women led by young student activist Annie Nathan Meyer, who petitioned Columbia ...
in New York, New York in 1963. She earned the doctoral degree in Chemistry under the direction of George Hein at
Boston University Boston University (BU) is a private research university in Boston, Massachusetts. The university is nonsectarian, but has a historical affiliation with the United Methodist Church. It was founded in 1839 by Methodists with its original campu ...
in Boston, Massachusetts in 1969.


Academic career

Following postdoctoral research appointments at the Fakultat der Universitat Munchen in Munich, Germany and at the
Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the ...
(MIT) in Cambridge, Massachusetts, she became Instructor and Senior Lecturer in the Department of Chemistry at MIT. She joined the faculty at
Brandeis University , mottoeng = "Truth even unto its innermost parts" , established = , type = Private research university , accreditation = NECHE , president = Ronald D. Liebowitz , pro ...
in 1990 as Lucille P. Markey Associate Professor, promoted to Lucille P. Markey Professor in 1994. She became the Harold and Bernice Davis Professor in Aging and Neurodegenerative Disease at Brandeis University in 2006.


Service to the discipline

Ringe served as Co-Chair of the Gordon Research Conference on Enzymes, Co-enzymes and Metabolic Pathways in 1994 and was a member of the Board of Trustees of the
Gordon Research Conferences Gordon Research Conferences are a group of international scientific conferences organized by a non-profit organization of the same name. The conference topics cover frontier research in the biological, chemical, and physical sciences, and the ...
(2000-2006). She was a Program Officer for the Program in Biophysics, Molecular and Cellular Biosciences, Division of Biology at the
National Science Foundation The National Science Foundation (NSF) is an independent agency of the United States government that supports fundamental research and education in all the non-medical fields of science and engineering. Its medical counterpart is the National I ...
(NSF) in 1997, 2000-2001 and 2010-2011 and served as Deputy Division Director, Molecular and Cellular Biosciences, Division of Biology, NSF, from 2012-2014. She was an Associate Editor of the
Biophysical Journal The ''Biophysical Journal'' is a biweekly peer-reviewed scientific journal published by Cell Press on behalf of the Biophysical Society. The journal was established in 1960 and covers all aspects of biophysics. The journal occasionally publis ...
(1999-2006) and is an editorial Board member of the Protein Journal and Scientific Reports. She served as an advisor for the TV mini-series documentary, The Mystery of Matter: Search for the Elements.


Contributions to science

Ringe has made extensive contributions to understanding the structure and function of enzymes. Her recent work has centered on understanding the functions of proteins associated with neurodegenerative diseases, including Alzheimer's, Lou Gehrig's, and Parkinson's. She co-authored a 2015 study revealing a potential novel approach to the treatment of
Parkinson's disease Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms becom ...
and identified new pathways in Parkinson's. She has also discovered potential new drugs to stop the protein aggregation that leads to
Alzheimer's disease Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term me ...
.Potential Alzheimer's Drug Spurs Protein Recycling
/ref>


Honors

*
Biophysical Society The Biophysical Society is an international scientific society whose purpose is to lead the development and dissemination of knowledge in biophysics. Founded in 1958, the Society currently consists of over 7,500 members in academia, government, an ...
Margaret Oakley Dayhoff Award (1985) *
Guggenheim Fellowship Guggenheim Fellowships are grants that have been awarded annually since by the John Simon Guggenheim Memorial Foundation to those "who have demonstrated exceptional capacity for productive scholarship or exceptional creative ability in the ar ...
of the
John Simon Guggenheim Memorial Foundation The John Simon Guggenheim Memorial Foundation was founded in 1925 by Olga and Simon Guggenheim in memory of their son, who died on April 26, 1922. The organization awards Guggenheim Fellowship Guggenheim Fellowships are grants that have been ...
(1997) * Fellow of the
American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...
(since 2005) * Abram L. Sachar Medallion from Brandeis University (2006) * Alexander von Humboldt Forshingspreis (2006)


Books

* Reactions and Syntheses in the Organic Chemistry Laboratory, L.F. Tietze and Th. Eichler, translated by Dagmar Ringe, University Science Books, Mill Valley, CA, 1989. * Primers in Biology: Protein Structure and Function, Gregory A. Petsko and Dagmar Ringe, New Science Ltd., London, 2004 * Cooperative Stewardship, National Research Council Report, J.J. Wise, Chair, 1999 * "Bridges to Independence: Fostering the Independence of New Investigators in Biomedical Research." National Research Council Report, 2005 * Bridging the Sciences, Report of the Interagency Coordinating Committee, Nov 9, 2004, NIH/NIBIB, NSF. * Drug Design: Structure- and Ligand-Based Approaches, K.M.Merz, D. Ringe, C.H.Reynolds, eds. Cambridge University Press (2010).


References


External links


Brandeis University FacultyDagmar Ringe, Ph.D., Michael J. Fox Foundation granteePotential Alzheimer's Drug Spurs Protein Recycling
{{DEFAULTSORT:Ringe, Dagmar 1942 births Living people American women chemists American women biochemists Barnard College alumni 21st-century American women