The DAF-3 or Dwarfin sma is a
nematode
The nematodes ( or grc-gre, Νηματώδη; la, Nematoda) or roundworms constitute the phylum Nematoda (also called Nemathelminthes), with plant-Parasitism, parasitic nematodes also known as eelworms. They are a diverse animal phylum inhab ...
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Caenorhabditis elegans
''Caenorhabditis elegans'' () is a free-living transparent nematode about 1 mm in length that lives in temperate soil environments. It is the type species of its genus. The name is a blend of the Greek ''caeno-'' (recent), ''rhabditis'' (ro ...
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gene encoding a Co-SMAD
protein of
TGF-beta signaling pathway. Without
daf-7 signal, DAF-3 combined with
transcription factor daf-5
Daf-5 is an ortholog of the mammalian protein Sno/Ski，which present in the nematode worm ''Caenorhabditis elegans'' on the downstream of TGFβ signaling pathway
The transforming growth factor beta (TGFB) signaling pathway is involved in many ...
to form a heterodimer and started
dauer development. When daf-7 binds to the receptors
daf-1
The DAF-1 gene encodes for a cell surface Enzyme-linked receptor of TGF-beta signaling pathway in the worm ''Caenorhabditis elegans''. DAF-1 is one of the type I receptor of TGF-beta pathway. DAF-1 acts as a receptor protein serine/threonine ki ...
/
daf-4, the
phosphorylated daf-8/
daf-14 heterodimer enter to the
nucleus
Nucleus ( : nuclei) is a Latin word for the seed inside a fruit. It most often refers to:
*Atomic nucleus, the very dense central region of an atom
*Cell nucleus, a central organelle of a eukaryotic cell, containing most of the cell's DNA
Nucle ...
to inhibit this transcription.
References
Caenorhabditis elegans genes
{{Gene-stub