DU145 (DU-145) is a human prostate cancer cell line. DU145,

PC3 PC3 (PC-3) is a human prostate cancer Cell culture#Isolation of cells, cell line used in prostate cancer research and drug development. PC3 cells are useful in investigating biochemical changes in advanced prostate cancer cells and in assessing t ...

, and

LNCaP LNCaP cells are a cell line of human cells commonly used in the field of oncology. LNCaP cells are androgen-sensitive human prostate adenocarcinoma cells derived from the left supraclavicular lymph node metastasis from a 50-year-old caucasian ma ...

are considered to be the standard prostate cancer cell lines used in therapeutic research. The DU145 cell line was derived from a central nervous system

metastasis Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, then ...

, of primary prostate adenocarcinoma origin, removed during a parieto-occipital craniotomy. DU145 are not hormone-sensitive and do not express

prostate-specific antigen Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the ''KLK3'' gene. PSA is a member of the kallikrein-related peptidase family and is secreted b ...

(PSA). DU145 cells have moderate

metastatic Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, then, ...

potential compared to PC3 cells, which have high metastatic potential. DU145 cells are androgen receptor positive.

References

External links

Cellosaurus entry for DU145
Human cell lines Cancer research Urology Prostate cancer {{cell-biology-stub