Dipeptidyl-peptidase 3 is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''DPP3''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
This gene encodes a protein that is a member of the S9B family in clan SC of the
serine protease
Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins. Serine serves as the nucleophilic amino acid at the (enzyme's) active site.
They are found ubiquitously in both eukaryotes and prokaryotes. ...
s. This
cytoplasmic
In cell biology, the cytoplasm is all of the material within a eukaryotic cell, enclosed by the cell membrane, except for the cell nucleus. The material inside the nucleus and contained within the nuclear membrane is termed the nucleoplasm. Th ...
protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline
dipeptidyl aminopeptidase Dipeptidyl peptidase is a type of enzyme classified under EC 3.4.14.
Types include:
* Cathepsin C, dipeptidyl peptidase-1
* Dipeptidyl-peptidase II
* DPP3, dipeptidyl peptidase-3
* DPP4, Dipeptidyl peptidase-4
* DPP6, dipeptidyl peptidase-6
* DPP ...
activity, cleaving Xaa-Pro dipeptides from the
N-termini
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide. Within a peptide, the amin ...
of proteins. Increased activity of this protein is associated with
endometrial
The endometrium is the inner epithelial layer, along with its mucous membrane, of the mammalian uterus. It has a basal layer and a functional layer: the basal layer contains stem cells which regenerate the functional layer. The functional layer ...
and
ovarian cancer
Ovarian cancer is a cancerous tumor of an ovary. It may originate from the ovary itself or more commonly from communicating nearby structures such as fallopian tubes or the inner lining of the abdomen. The ovary is made up of three different c ...
s. Alternate transcriptional splice variants have been characterized.
References
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External links
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