TRNA (cytosine38-C5)-methyltransferase (, ''hDNMT2 (gene)'', ''DNMT2 (gene)'', ''
TRDMT1
tRNA (cytosine-5-)-methyltransferase is an enzyme that in humans is encoded by the ''TRDMT1'' gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''gen ...
(gene)'') is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
with the
systematic name ''S-adenosyl-L-methionine:tRNA (cytosine38-C5)-methyltransferase''.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...
:
:
S-adenosyl-L-methionine +
cytosine
Cytosine () ( symbol C or Cyt) is one of the four nucleobases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA). It is a pyrimidine derivative, with a heterocyclic aromatic ring and two substituents attached (an am ...
38 in tRNA
S-adenosyl-L-homocysteine +
5-methylcytosine38 in tRNA
The eukaryotic enzyme catalyses
methylation
In the chemical sciences, methylation denotes the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group. Methylation is a form of alkylation, with a methyl group replacing a hydrogen atom. These t ...
of cytosine
38 in the anti-codon loop of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC).
See also
*
TRDMT1
tRNA (cytosine-5-)-methyltransferase is an enzyme that in humans is encoded by the ''TRDMT1'' gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''gen ...
References
External links
*
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EC 2.1.1