DMPX (3,7-dimethyl-1-propargylxanthine) is a
caffeine
Caffeine is a central nervous system (CNS) stimulant of the methylxanthine class. It is mainly used recreationally as a cognitive enhancer, increasing alertness and attentional performance. Caffeine acts by blocking binding of adenosine t ...
analog which displays affinity to A
2 adenosine receptor
The adenosine receptors (or P1 receptors) are a class of purinergic G protein-coupled receptors with adenosine as the endogenous ligand. There are four known types of adenosine receptors in humans: A1, A2A, A2B and A3; each is encoded by a di ...
s, in contrast to the A
1 subtype receptors.
DMPX had 28× and 15× higher potency than caffeine in blocking peripheral and central
NECA-responses. The locomotor stimulation caused by DMPX (ED
50 10 ''μ''mol/kg) was similarly higher than caffeine.
See also
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DPCPX
8-Cyclopentyl-1,3-dipropylxanthine (DPCPX, PD-116,948) is a drug which acts as a potent and selective antagonist for the adenosine A1 receptor. It has high selectivity for A1 over other adenosine receptor subtypes, but as with other xanthine ...
*
8-PT
*
CPX (8-CPT)
*
8-Chlorotheophylline
8-Chlorotheophylline, also known as 1,3-dimethyl-8-chloroxanthine, is a stimulant drug of the xanthine chemical class, with physiological effects similar to caffeine. Its main use is in combination (salt) with diphenhydramine in the antiemetic d ...
*
Theophylline
Theophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. As a member of the ...
References
{{Adenosinergics
Adenosine receptor antagonists
Anxiogenics
Caffeine
Designer drugs
Vasoconstrictors
Propargyl compounds