DHA-clozapine (tentative trade name Clozaprexin)
is an atypical
antipsychotic
Antipsychotics, also known as neuroleptics, are a class of psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia but also in a range of ...
drug candidate that was created and originally tested by chemists at Protarga, a small pharmaceutical in Pennsylvania, and scientists at Harvard University.
It is a
prodrug of
clozapine
Clozapine is a psychiatric medication and is the first atypical antipsychotic (also called second-generation antipsychotic). It is primarily used to treat people with schizophrenia and schizoaffective disorders who have had an inadequate respo ...
; the fatty acid
docosahexaenoic acid
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina. In physiological literature, it is given the name 22:6(n-3). It can be synthesized from alpha-lin ...
(DHA) was added to clozapine in order to increase penetration of the
blood–brain barrier.
Protarga was purchased by Luitpold Pharmaceuticals in 2003 and development was discontinued in 2007.
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References
Atypical antipsychotics
Chloroarenes
Dibenzodiazepines
Dopamine antagonists
Piperazines
Prodrugs
Serotonin receptor antagonists
Abandoned drugs
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