The human ''DEK'' gene encodes the DEK
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
.
Function
This gene encodes a protein with one SAP domain. The protein binds to cruciform and superhelical
DNA and induces positive supercoils into closed circular DNA. It is also involved in splice site selection during
mRNA
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of synthesizing a protein.
mRNA is created during the ...
processing. Chromosomal aberrations involving this region increased expression of this gene and the presence of antibodies against this protein are all associated with various diseases.
Interactions
''DEK''
interacts with
TFAP2A
Transcription factor AP-2 alpha (Activating enhancer binding Protein 2 alpha), also known as TFAP2A, is a protein that in humans is encoded by the ''TFAP2A'' gene.
Function
Transcription factor AP-2 alpha is a 52-kD sequence-specific DNA-bindi ...
.
References
Further reading
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External links
PDBe-KBprovides an overview of all the structure information available in the PDB for Human Protein DEK
{{gene-6-stub
Oncogenes