DAnCER (disease-annotated
chromatin
Chromatin is a complex of DNA and protein found in eukaryote, eukaryotic cells. The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important ...
epigenetics
In biology, epigenetics is the study of stable phenotypic changes (known as ''marks'') that do not involve alterations in the DNA sequence. The Greek prefix '' epi-'' ( "over, outside of, around") in ''epigenetics'' implies features that are " ...
resource) is a database for
chromatin
Chromatin is a complex of DNA and protein found in eukaryote, eukaryotic cells. The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important ...
modifications and their relation to human disease.
It was developed by the
Wodak Lab at the
Hospital for Sick Children.
It has been developed to serve as the core bioinformatics resource for seven experimental and bioinformatics laboratories working together to unravel the mechanisms of chromatin modifications and their relation to human disease. Since molecular networks are essential to the understanding of biological processes, this research effort strives to explore CM-related genes in the full context of protein complexes, gene-expression regulation and pathways. To gain additional insights into the CM process in human cells, it also explores patterns of evolutionary conservation across model organisms - from sequence, domain composition and 3D structure, to interaction patterns and regulatory mechanisms.
See also
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Epigenomics
Epigenomics is the study of the complete set of epigenetic modifications on the genetic material of a cell, known as the epigenome. The field is analogous to genomics and proteomics, which are the study of the genome and proteome of a cell. Epigen ...
*
chromatin
Chromatin is a complex of DNA and protein found in eukaryote, eukaryotic cells. The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important ...
References
External links
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Genetics databases
Nuclear substructures
Epigenetics
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