D-amino acid oxidase activator (DAOA, also known as G72) is a protein enriched in various parts of brain, spinal cord, and testis. DAOA is thought to interact with

D-amino acid oxidase D-amino acid oxidase (DAAO; also OXDA, DAMOX) is an enzyme with the function on a molecular level to oxidize D-amino acids to the corresponding α-keto acids, producing ammonia and hydrogen peroxide. This results in a number of physiological e ...

, a peroxisomal enzyme, and its gene was associated with

schizophrenia Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social withdra ...

in a number of studies.Gene Overview of All Published Schizophrenia-Association Studies for DAOA
, schizophreniaforum.org In separate studies it has been shown to confer susceptibility to bipolar disorder. Therefore, it has been important in researching whether the Kraepelinian dichotomy is genuine. The gene itself was discovered during an investigation of chromosomal 13q22-q34 region, which was previously linked to schizophrenia. G72 is transcribed into several proteins due to

alternative splicing Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single gene to code for multiple proteins. In this process, particular exons of a gene may be ...

; the longest protein is called LG72 and consists of 153 amino acids. Although the protein was initially found to interact with DAO in yeast 2-hybrid experiment, one recent in vivo experiment showed LG72 presence only in mitochondria and failed to confirm the interaction.

References

External links

* From schizophrenia research forum website: *
G72 Protein Shows Up in Mitochondria
*
Genetic Studies of DAOA(G72)/G30 Bridge Kraepelinian Divide
Proteins Biology of bipolar disorder {{gene-13-stub

See also

References

External links