-Deprenyl, also known as or ''dextro''-''N''-propargyl-''N''-methylamphetamine, is an

MAO-B Monoamine oxidase B, also known as MAOB, is an enzyme that in humans is encoded by the ''MAOB'' gene. The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is an enzyme located in the outer mitochondrial membrane. I ...

inhibitor that metabolizes into -amphetamine and -methamphetamine and is therefore also a

norepinephrine–dopamine releasing agent A norepinephrine–dopamine releasing agent (NDRA) is a type of drug which induces the release of norepinephrine (and epinephrine) and dopamine in the body and/or brain. Examples of NDRAs include phenethylamine, tyramine, amphetamine, methampheta ...

. It is the opposite

enantiomer In chemistry, an enantiomer ( /ɪˈnænti.əmər, ɛ-, -oʊ-/ ''ih-NAN-tee-ə-mər''; from Ancient Greek ἐνάντιος ''(enántios)'' 'opposite', and μέρος ''(méros)'' 'part') – also called optical isomer, antipode, or optical ant ...

of -deprenyl (selegiline). -Deprenyl, also an MAO-B inhibitor, metabolizes to -amphetamine and -methamphetamine, which are both

norepinephrine releasing agent A norepinephrine releasing agent (NRA), also known as an adrenergic releasing agent, is a catecholaminergic type of drug that induces the release of norepinephrine (noradrenaline) and epinephrine (adrenaline) from the pre-synaptic neuron into ...

s. In contrast, -deprenyl additionally has dopaminergic effects and has been found to be

reinforcing In behavioral psychology, reinforcement is a consequence applied that will strengthen an organism's future behavior whenever that behavior is preceded by a specific antecedent stimulus. This strengthening effect may be measured as a higher freq ...

in scientific research, whereas -deprenyl is not known to have any appreciable psychological reinforcement. In addition to its actions as an MAO-B inhibitor and NDRA, -deprenyl has been found to bind with high

affinity Affinity may refer to: Commerce, finance and law * Affinity (law), kinship by marriage * Affinity analysis, a market research and business management technique * Affinity Credit Union, a Saskatchewan-based credit union * Affinity Equity Par ...

to the σ₁ receptor (K_i = 79 nM) similarly to various other amphetamine derivatives. Its -isomer, selegiline, binds with 3.5-fold lower affinity in comparison.

References

Propargyl compounds Enantiopure drugs Monoamine oxidase inhibitors Norepinephrine-dopamine releasing agents Phenethylamines Prodrugs Sigma receptor ligands {{nervous-system-drug-stub

See also

References