John Dirks Yoshinori Osumi Kenjiro Monji and D Lorne Tyrrell 20151029

David Lorne John Tyrrell (born 1943) is a Canadian physician.

Overview

Born on February 10, 1943, in

Edmonton Edmonton ( ) is the capital city of the Canadian province of Alberta. Edmonton is situated on the North Saskatchewan River and is the centre of the Edmonton Metropolitan Region, which is surrounded by Alberta's central region. The city an ...

Alberta Alberta ( ) is one of the thirteen provinces and territories of Canada. It is part of Western Canada and is one of the three prairie provinces. Alberta is bordered by British Columbia to the west, Saskatchewan to the east, the Northwest T ...

, he grew up on the family farm near Duffield and studied at the

University of Alberta The University of Alberta, also known as U of A or UAlberta, is a Public university, public research university located in Edmonton, Alberta, Canada. It was founded in 1908 by Alexander Cameron Rutherford,"A Gentleman of Strathcona – Alexande ...

. Tyrrell interned at the University of Alberta Hospital and then went on to earn a

PhD PHD or PhD may refer to: * Doctor of Philosophy (PhD), an academic qualification Entertainment * '' PhD: Phantasy Degree'', a Korean comic series * '' Piled Higher and Deeper'', a web comic * Ph.D. (band), a 1980s British group ** Ph.D. (Ph.D. al ...

pharmacology Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...

from Queen's University in 1972. He returned to Alberta in 1975 to train in internal medicine. From 1982 to 1994, he was director of the Infectious Diseases division and later the Department of Medical Microbiology and Immunology at the University of Alberta. In 1994, he became dean of the faculty of medicine at the university. In 2010, he secured a large donation for the university which established the Li Ka Shing Institute of Virology. Tyrrell's research into viral hepatitis lead to the development of the oral antiviral drug

lamivudine Lamivudine, commonly called 3TC, is an antiretroviral medication used to prevent and treat HIV/AIDS. It is also used to treat chronic hepatitis B when other options are not possible. It is effective against both HIV-1 and HIV-2. It is typicall ...

. This treatment enabled the use of

liver transplant Liver transplantation or hepatic transplantation is the replacement of a diseased liver with the healthy liver from another person (allograft). Liver transplantation is a treatment option for end-stage liver disease and acute liver failure, al ...

s for persons infected with

Hepatitis B Hepatitis B is an infectious disease caused by the '' Hepatitis B virus'' (HBV) that affects the liver; it is a type of viral hepatitis. It can cause both acute and chronic infection. Many people have no symptoms during an initial infection. ...

. In collaboration with Norman Miles Kneteman (University of Alberta, Department of Surgery), Tyrrell and his team contributed to the development of a mouse with a humanized liver to be used for testing drugs to treat

Hepatitis C Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver; it is a type of viral hepatitis. During the initial infection people often have mild or no symptoms. Occasionally a fever, dark urine, ...

. He was named to the

Alberta Order of Excellence The Alberta Order of Excellence (french: Ordre d'excellence de l'Alberta) is a civilian honour for merit in the Canadian province of Alberta. Instituted in 1979 when Lieutenant Governor Frank C. Lynch-Staunton granted royal assent to the Alberta O ...

in 2000 and became an officer in the

Order of Canada The Order of Canada (french: Ordre du Canada; abbreviated as OC) is a Canadian state order and the second-highest honour for merit in the system of orders, decorations, and medals of Canada, after the Order of Merit. To coincide with the cen ...

in 2002. Tyrrell became a fellow of the

Royal Society of Canada The Royal Society of Canada (RSC; french: Société royale du Canada, SRC), also known as the Academies of Arts, Humanities and Sciences of Canada (French: ''Académies des arts, des lettres et des sciences du Canada''), is the senior national, bil ...

in 2004. In 2009, he was named chair of the board of directors for the

Gairdner Foundation The Gairdner Foundation is a non-profit organization devoted to the recognition of outstanding achievements in biomedical research worldwide. It was created in 1957 by James Arthur Gairdner to recognize and reward the achievements of medical resea ...

. Tyrrell was inducted into the

Canadian Medical Hall of Fame __NOTOC__ The Canadian Medical Hall of Fame is a Canadian charitable organization, founded in 1994, that honours Canadians who have contributed to the understanding of disease and improving the health of people. It has an exhibit hall in London, O ...

in 2011. He was a

Killam Prize The Izaak Walton Killam Memorial Prize was established according to the will of Dorothy J. Killam to honour the memory of her husband Izaak Walton Killam. Five Killam Prizes, each having a value of $100,000, are annually awarded by the Canada Co ...

winner in 2015.

References

{{DEFAULTSORT:Tyrrell, D. Lorne 1935 births Living people Canadian infectious disease physicians Fellows of the Royal Society of Canada Members of the Alberta Order of Excellence Officers of the Order of Canada People from Edmonton Queen's University at Kingston alumni University of Alberta alumni