Cytochalasin D is a member of the class of
mycotoxins known as
cytochalasins. Cytochalasin D is an
alkaloid produced by
Helminthosporium and other molds.
Cytochalasin D is a cell-permeable and potent inhibitor of
actin polymerization. It disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. It is believed to bind to
F-actin polymer and prevent polymerization of actin monomers.
References
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Mycotoxins
Actin inhibitors
Acetate esters
Vinylidene compounds