Ceragenins, or cationic steroid antimicrobials (CSAs), are synthetically-produced, small-molecule chemical compounds consisting of a sterol backbone with amino acids and other chemical groups attached to them. These compounds have a net positive charge that is electrostatically attracted to the negative-charged cell membranes of certain viruses, fungi and bacteria. CSAs have a high binding affinity for such membranes (including

Lipid A Lipid A is a lipid component of an endotoxin held responsible for the toxicity of gram-negative bacteria. It is the innermost of the three regions of the lipopolysaccharide (LPS), also called endotoxin molecule, and its hydrophobic nature allows it ...

) and are able to rapidly disrupt the target membranes leading to rapid cell death. While CSAs have a mechanism of action that is also seen in antimicrobial peptides, which form part of the body's innate immune systum, they avoid many of the difficulties associated with their use as medicines. Ceragenins were discovered by Paul B. Savage of

Brigham Young University Brigham Young University (BYU, sometimes referred to colloquially as The Y) is a private research university in Provo, Utah. It was founded in 1875 by religious leader Brigham Young and is sponsored by the Church of Jesus Christ of Latter-d ...

's Department of Chemistry and Biochemistry. In data previously presented by Savage and other researchers, CSAs were shown to have broad-spectrum antibacterial activity. Derya Unutmaz, Associate Professor of Microbiology and Immunology at the

Vanderbilt University School of Medicine Vanderbilt University School of Medicine is a graduate medical school of Vanderbilt University located in Nashville, Tennessee. Located in the Vanderbilt University Medical Center on the southeastern side of the Vanderbilt University campus, the ...

, tested several CSAs in his laboratory for their ability to kill

HIV The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune ...

directly. Unutmaz said in 2006 "We have some preliminary but very exciting results. But we would like to formally show this before making any claims that would cause unwanted hype." On February 6, 2006, researchers including Savage announced, before

peer review Peer review is the evaluation of work by one or more people with similar competencies as the producers of the work ( peers). It functions as a form of self-regulation by qualified members of a profession within the relevant field. Peer revie ...

, that a ceragenin compound, CSA-54, appeared to inactivate HIV.

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* * {{Antiretroviral drug Antibiotics Steroids