Casa Sollievo della Sofferenza (English: ''"Home for Relief of Suffering"'') is a private scientific research hospital in San Giovanni Rotondo,

Italy Italy ( it, Italia ), officially the Italian Republic, ) or the Republic of Italy, is a country in Southern Europe. It is located in the middle of the Mediterranean Sea, and its territory largely coincides with the homonymous geographical ...

, founded by

Saint Pio of Pietrelcina Francesco Forgione, OFM Cap., better known as Padre Pio and as Saint Pius of Pietrelcina ( it, Pio da Pietrelcina; 25 May 188723 September 1968), was an Italian Franciscan Capuchin friar, priest, stigmatist, and mystic. He is venerated as a s ...

, and administered by

Vatican City Vatican City (), officially the Vatican City State ( it, Stato della Città del Vaticano; la, Status Civitatis Vaticanae),—' * german: Vatikanstadt, cf. '—' (in Austria: ') * pl, Miasto Watykańskie, cf. '—' * pt, Cidade do Vati ...

. Inaugurated on 5 May 1956, the hospital has adopted modern technologies and is often considered as one of the most efficient scientific research hospitals in

Europe Europe is a large peninsula conventionally considered a continent in its own right because of its great physical size and the weight of its history and traditions. Europe is also considered a Continent#Subcontinents, subcontinent of Eurasia ...

. The building is situated at the highest part of the town, on the top of the hill, giving the location an identity of a hospital-town. Casa Sollievo della Sofferenza has two major activity wings. One of which is an internationally regarded hospital for the relief of suffering and the other is a state-of-the-art scientific research centre which had received the status of a Scientific Hospitalization and Treatment Institute (IRCCS), an institute of national interest, by the decree of Italian Ministry of Health in 1991. The research centre is also home to the Genomic and Genetic Disorders Biobank which is part of the Telethon Network of Genetic Biobanks and conducts basic and pre-clinical research and clinical trials in collaboration with pharmaceutical companies. It is first in the world to run non-profit clinical trials. The hospital has established Institute for Stem-cell Biology, Regenerative Medicine and Innovative Therapies (ISBReMIT) that will be the first factory of GMP neural stem cells in Europe for producing bio-drugs and cell-drugs. ISBReMIT has a dedicated area for the start-ups and spin-offs in biotechnology. Casa Sollievo della Sofferenza also houses a large out-patient clinic, a hospital-school for the children suffering from cancer and other genetic disorders, a reception centre which is a hotel complex, and a social-assistance residence for elderly. Casa Sollievo della Sofferenza also owns two agricultural companies-Masseria Calderoso and Posta La Via. It also hosts one spiritual centre, prayer group and a church. In front of Casa Sollievo della Sofferenza there is

Sanctuary of Saint Pio of Pietrelcina The Sanctuary of Saint Pio of Pietrelcina (sometimes referred to as Padre Pio Pilgrimage Church) is a Catholic shrine in San Giovanni Rotondo, Province of Foggia, Italy, owned by the Order of Friars Minor Capuchin. Its surface area is 6,000 squar ...

, named after the founder of this hospital and research centre.

Hospital

The hospital manages 900 beds, 206 elderly care beds, 2900 employees, 60000 annual admissions, 9500 surgeries per year, and over 1.3 million annual outpatient services, making it one among the most regarded in

. The hospital is divided among 30 medical and surgical wards, 50 clinical specialities, and 4300 diagnostic and therapeutic services."

Departments and services

The hospital has the following departments- Health Management, Pathological anatomy, Anesthesia and resuscitation I, Anesthesia and Resuscitation II, Cordonal Bank, Banca del Latte, Cardiac Surgery, Cardiology UTIC, PET / TAC Center, Transfusion Center, Abdominal surgery, Maxillofacial Surgery, Breast Surgery, Thoracic Pulmonary Surgery, Vascular surgery, Dermatology, Electrophysiology, Hematology, Hemodynamics, Hemostasis and Thrombosis, Endocrinology, Digestive Endoscopy, Hepatology, Health physics, Gastroenterology, Medical Genetics, Geriatrics, Analysis Laboratory, Internal Medicine, Nuclear Medicine, Nephrology and Dialysis, Neonatology, Neurosurgery, Neurology, Ophthalmology, Dentistry, Pediatric Oncohematology, Oncology, Orthopedics and Traumatology, Obstetrics and Gynecology, Otolaryngology, Pediatrics, Emergency room, Diagnostic Radiology, Interventional Radiology, Radiotherapy, Cardiological rehabilitation, Functional rehabilitation, and Urology. KOS San Giovanni Rotondo

Assistive Robotics and Artificial Intelligence in Patient Care

Casa Sollievo della Sofferenza has taken an initiative to get into the activities of assistive robotics and artificial intelligence in the care sector in partnership with Konica Minolta Inc. and IIT - Istituto Italiano di Tecnologia. They have welcomed Konica Minolta Laboratory Europe to install robotics facility within the hospital. The robotic setup will accompany a patient during their daily routines.

Agile Co-Creation for Robots and Aging

This project is a European Union and Japan cooperation programme and includes- Casa Sollievo della Sofferenza, Italy, The BioRobotics Institute, Italy, Erasmus University Rotterdam, The Netherlands, Université Paris-Dauphine, France, TRIALOG Paris, France, Kyoto University, Japan, and Connectdot Ltd, Japan. The aim of this project is to implement robotics and artificial intelligence in assistive healthcare.

Research

The Casa Sollievo della Sofferenza Hospital is an IRCCS (Istituto di ricovero e cura a carattere scientifico) research centre of Italian Ministry of Health, an institute of national interest, for "Genetic diseases, innovative therapies and regenerative medicine" and received annual funding of 150 Million Euro in 2017. The hospital received IRCCS status in 1991 from the Italian Ministry of Health. There are 146 researchers who are (or were) affiliated with IRCCS Casa Sollievo della Sofferenza contributing to the total research output of more than 6500 publications in the areas of life sciences & medicine so far. It publishes 170 scientific papers per year on average in the areas of life sciences and medicine, and many of them get published in very high-impact factor journals like ''

Nature Nature, in the broadest sense, is the physical world or universe. "Nature" can refer to the phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. Although humans are ...

'', ''

New England Journal of Medicine ''The New England Journal of Medicine'' (''NEJM'') is a weekly medical journal published by the Massachusetts Medical Society. It is among the most prestigious peer-reviewed medical journals as well as the oldest continuously published one. His ...

'', ''Lancet'' and ''

Science Science is a systematic endeavor that builds and organizes knowledge in the form of testable explanations and predictions about the universe. Science may be as old as the human species, and some of the earliest archeological evidence ...

''. IRCCS Casa Sollievo della Sofferenza maintains direct research collaboration with almost all Italian universities and other IRCCS, and many other academic and corporate institutes outside the Italy like

Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of highe ...

Broad Institute The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States. The insti ...

of MIT and Harvard,

University of Oxford , mottoeng = The Lord is my light , established = , endowment = £6.1 billion (including colleges) (2019) , budget = £2.145 billion (2019–20) , chancellor ...

University of Cambridge , mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Schola ...

Hoffmann-La Roche F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has shares listed on the SIX ...

Gilead Sciences Gilead Sciences, Inc. () is an American biopharmaceutical company headquartered in Foster City, California, that focuses on researching and developing antiviral drugs used in the treatment of HIV/AIDS, hepatitis B, hepatitis C, influenza, and CO ...

Biogen Biogen Inc. is an American multinational biotechnology company based in Cambridge, Massachusetts, specializing in the discovery, development, and delivery of therapies for the treatment of neurological diseases to patients worldwide. History ...

Novartis Novartis AG is a Swiss-American multinational pharmaceutical corporation based in Basel, Switzerland and Cambridge, Massachusetts, United States (global research).name="novartis.com">https://www.novartis.com/research-development/research-loc ...

University of Sydney The University of Sydney (USYD), also known as Sydney University, or informally Sydney Uni, is a public research university located in Sydney, Australia. Founded in 1850, it is the oldest university in Australia and is one of the country's si ...

Osaka University , abbreviated as , is a public research university located in Osaka Prefecture, Japan. It is one of Japan's former Imperial Universities and a Designated National University listed as a "Top Type" university in the Top Global University Project. ...

and many other research institutes of high-repute in

United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territorie ...

and

Asia Asia (, ) is one of the world's most notable geographical regions, which is either considered a continent in its own right or a subcontinent of Eurasia, which shares the continental landmass of Afro-Eurasia with Africa. Asia covers an area ...

Clinical trials

Casa Sollievo della Sofferenza conducts clinical trials in collaboration with pharmaceutical companies. At present, there are more than 200 clinical trials in progress in the areas like

amyotrophic lateral sclerosis Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) or Lou Gehrig's disease, is a neurodegenerative disease that results in the progressive loss of motor neurons that control voluntary muscles. ALS is the most comm ...

multiple sclerosis Multiple (cerebral) sclerosis (MS), also known as encephalomyelitis disseminata or disseminated sclerosis, is the most common demyelinating disease, in which the insulating covers of nerve cells in the brain and spinal cord are damaged. This d ...

glioblastoma Glioblastoma, previously known as glioblastoma multiforme (GBM), is one of the most aggressive types of cancer that begin within the brain. Initially, signs and symptoms of glioblastoma are nonspecific. They may include headaches, personality ch ...

and

Huntington's disease Huntington's disease (HD), also known as Huntington's chorea, is a neurodegenerative disease that is mostly inherited. The earliest symptoms are often subtle problems with mood or mental abilities. A general lack of coordination and an unst ...

. There are 171 published articles from Casa Sollievo della Sofferenza that have involved Clinical Trials of Phase I or II and 25 published articles that have involved successful Phase III Clinical Trials so far. Non-profit clinical trials
IRCCS Casa Sollievo della Sofferenza is also the first in the world to run a not-for-profit Phase I Clinical Trial on transplantation of neural stem cells for the patients who are suffering from Amyotrophic Lateral Sclerosis. Institute for Stem-Cell Biology, Regenerative Medicine and Innovative Therapies at Casa Sollievo della Sofferenza will also run non-profit clinical trials against sla, multiple sclerosis and

ISBReMIT (Institute for Stem-cell Biology, Regenerative Medicine and Innovative Therapies)

Casa Sollievo della Sofferenza has established ISBReMIT, a brand-new research centre for stem cells and regenerative medicine, with a grant of 14.4 Million Euro from Italian Ministry of Education, Universities and Research. ISBReMIT is the first factory of GMP

neural stem cells Neural stem cells (NSCs) are self-renewing, multipotent cells that firstly generate the radial glial progenitor cells that generate the neurons and glia of the nervous system of all animals during embryonic development. Some neural progenitor ste ...

and will produce the pharmaceutical grade cells which will be used in clinical trials. This research centre also has an area dedicated to start-up companies for the commercialisation of research. This new building is built between the John Paul II clinic and the hospital building of Casa Sollievo della Sofferenza. It has been structured to produce cellular therapies, gene therapies and prostheses made up of biomaterials, and will run non-profit clinical trials against sla, multiple sclerosis and

Cancer Stem Cell Unit at ISBReMIT

This unit of Casa Sollievo della Sofferenza is developing selective biopharmaceuticals. It is working in collaboration with two innovative startups StemGen,

and HyperStem SA,

Switzerland ). Swiss law does not designate a ''capital'' as such, but the federal parliament and government are installed in Bern, while other federal institutions, such as the federal courts, are in other cities (Bellinzona, Lausanne, Luzern, Neuchâtel ...

to revolutionize technology of cancer stem cells in experimentation on patients.

Medical Genetics Unit

Major activities of this research unit include-discovery of disease related genes, study of genomic signatures in disease pathology, analysis of deregulated pathyways in complex pathologies and functional studies of mutations in genes associated with tumour and other complex diseases. Dr. Giuseppe Merla, a scientist from IRCCS Casa Sollievo della Sofferenza Medical Genetics Unit led the discovery of a novel rare genetic syndrome- IDDCA (intellectual development disorder with cardiac arrhythmia) along with collaborators from America, the Netherlands, Brazil and Switzerland. In 2018, Oxford BioDynamics had signed a deal with Casa Sollievo della Sofferenza to develop a novel biomarker assay for Autism Spectrum Disorder (ASD).

Oncology Research Unit

Research interest of this unit is divided into three major areas-Epigenetic study of tumour development, molecular basis of chemoresistance in solid tumours, miRNA expression profiling in

colorectal cancer Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum (parts of the large intestine). Signs and symptoms may include blood in the stool, a change in bowel m ...

breast cancer Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a re ...

and

gliomas A glioma is a type of tumor that starts in the glial cells of the brain or the spine. Gliomas comprise about 30 percent of all brain tumors and central nervous system tumours, and 80 percent of all malignant brain tumours. Signs and symptoms ...

. The aim of this unit is to study identification of early markers by non-invasive analysis, characterization of

cancer stem cells Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sampl ...

, and develop customized molecular therapies. In 2018, as a member of the network Casa Sollievo della Sofferenza completed RESORT trial Phase II (A Randomized, Open Label, Multicenter Phase 2 Study, to Evaluate the Efficacy of Sorafenib in Patients With Advanced Renal Cell Carcinoma After a Radical Resection of the Metastases). IRCCS Casa Sollievo della Sofferenza has been recognized as one of the 20 highly specialized centres for diagnosis and treatment of colorectal cancer based on studying genetic and molecular detail using microchip technology.

Mendel Institute of Casa Sollievo della Sofferenza (CSS Mendel Institute)

Mission of this institute is to study and prevent rare diseases. Three major activities of this institute include-research, diagnosis and clinical consultancy. The institute has five major research units-Molecular Diagnostics Unit, Bioinformatics Unit, Cytogenetic Diagnostics Unit, Diabetes Research Unit, and iPS cellular programming research Unit.

Diabetology and Endocrinology Research Unit

This unit focuses its interest on epidemiological and genetic bases of type 2

diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...

and its cardio-nephro-vascular complications. It has carried out research on identification/characterization of some important genes like ENPP1, ADIPOQ,

TRIB3 Tribbles homolog 3 is a protein that in humans is encoded by the ''TRIB3'' gene. Function The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. It is a pseudoenzyme that is though ...

, RETN,

IRS1 Insulin receptor substrate 1 (IRS-1) is a signaling adapter protein that in humans is encoded by the ''IRS-1'' gene. It is a 131 kDa protein with amino acid sequence of 1242 residues. It contains a single pleckstrin homology (PH) domain at the N-te ...

and PPARgamma2 and also insulin signaling inhibitors such as ENPP1.

Hepatology Research Unit

Hepatology unit works on two thematic areas-responses to anti-viral therapy in hepatitis and genetics of hepatopathic patients. In 2009, the unit identified a novel marker of response to the anti-viral therapy of hepatitis C in collaboration with

Duke University Duke University is a private research university in Durham, North Carolina. Founded by Methodists and Quakers in the present-day city of Trinity in 1838, the school moved to Durham in 1892. In 1924, tobacco and electric power industrialist James ...

and

North Carolina North Carolina () is a state in the Southeastern region of the United States. The state is the 28th largest and 9th-most populous of the United States. It is bordered by Virginia to the north, the Atlantic Ocean to the east, Georgia and So ...

. The study led to discovery of variants of

IL28B Interferon lambda 3 (gene symbol: ''IFNL3)'' encodes the IFNL3 protein. ''IFNL3'' was formerly named ''IL28B'', but the Human Genome Organization Gene Nomenclature Committee renamed this gene in 2013 while assigning a name to the then newly disc ...

gene which is now widely used for prediction of response to the therapy. The unit has a long history performing clinically relevant research in Hepatology since the 1990s.

, one of the world's largest biotech companies maintains strong collaboration with Casa Sollievo della Sofferenza for research on HCV treatment. At the International Live Congress (ILC) 2019, Alessandra Mangia, MD, Chief of Liver Unit at IRCCS-Ospedale Casa Sollievo Della Sofferenza presented the data on role of Gilead HCV Medicines to reach the World Health Organization's goal of eliminating HCV globally by 2030.

Biostatistics & Bioinformatics Research Unit

This unit deals with the large scale clinical and genomic data. It manages and analyzes the data from clinical trials and research labs and also develops new algorithms. It operates the macro routines in SAS and R language and develops software for clinical trial design. It also deals with advanced statistical and computational methods in

genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar wor ...

and performs survival and longitudinal data analysis.

Genomic and Genetic Disorders Biobank

This biobank at Casa Sollievo della Sofferenza was established in 2006. In 2009, it became a member of Telethon Network of Genetic Biobanks, and RD-Connect International Community for rare diseases. It has a well-annotated internal database of clinical and longitudinal data and biological samples for multiple genomic disorders, genetic and Mendelian diseases.

Transfusion Medicine Unit

In 2019, this unit received 10 years of European accreditation from EFI (European Federation for Immunogenetics) for carrying out research in the field of hematopoietic stem cell transplants. HLA Immunogenetics Laboratory of the Transfusion Medicine Unit finished 6,000 immunogenetic analysis in 2018 only. The unit performs genomic typing of tissue compatibility that is translated into the search for the best possible donor from sample both genetically and clinically. It maintains an international registration for donors and has 4000 potential samples so far.

John Paul II outpatient clinic

"John Paul II" outpatient clinic is medical complex spread over 25000 square meters and manages over 1.3 million outpatient services per year. Built in 2002, this complex was a further step towards "Cittadella Ospedaliera", as desired by Saint Pio, the founder of Casa Sollievo della Sofferenza. This complex is entirely managed through open source technologies. With 60 speciality clinics the complex is managed through a single booking centre, and houses the most modern equipments in the world.

The School in the Hospital

Casa Sollievo della Sofferenza runs a school for the children suffering from cancer and other genetic diseases. The school is a section of the Hematology and Pediatric Oncology Unit. It has a school library, IT support and provides all kind of materials and facilities for creative and fun initiatives. This is a unique initiative of Casa Sollievo della Sofferenza.

S. Maria delle Grazie reception centre (hotel complex)

This is located just a few meters away from Casa Sollievo della Sofferenza. It has 217 beds divided into single and double rooms with private bathrooms, Conference hall, Chapel with Eucharist, Restaurant, TV room, Bar reserved for guests only, and Car parking with garage. Restaurant at Reception Center, Casa Sollievo della Sofferenza

Restaurant at Reception Center, Casa Sollievo della Sofferenza

Casa Padre Pio residence for the elderly

It offers a hotel-type hospitality service with full respect to personal freedom, human and Christian dignity. The services include-Reading room, TV room, library, conference room, gym with an instructor, bar & restaurant, a private chapel with daily Mass celebration, spiritual and religious guidance, fully guaranteed social and health assistance, laundry and hairdresser for men and women. The first stone of this residence was blessed by

Pope John Paul II Pope John Paul II ( la, Ioannes Paulus II; it, Giovanni Paolo II; pl, Jan Paweł II; born Karol Józef Wojtyła ; 18 May 19202 April 2005) was the head of the Catholic Church and sovereign of the Vatican City State from 1978 until his ...

on May 23, 1987.

The agricultural activity of the Casa Sollievo della Sofferenza

Casa Sollievo della Sofferenza owns and runs two agritultural companies: Masseria Calderoso and Posta la Via.

Masseria Calderoso

The Masseria Calderoso farm extends over 71 hectares with about 9,400 olive trees of the Peranzana, Ogliarola Garganica and Rotondella varieties. The farm produces extra virgin olive oil, strictly through biological production methods, which is used by the Casa Sollievo della Sofferenza Hospital and its associated facilities.

Posta la Via

Posta la Via, spread over more than 200 hectares of area, is divided into three sectors-agricultural, livestock and dairy. The agricultural sector is responsible for organic cultivation. The livestock supplies dairy cattle and fattening calves. The dairy unit produces dairy products (mozzarella, ricotta, caciocavalli, caciottine, butter, crescenza, yogurt, puddings and ice cream).

References

External links

Official website

Official YouTube Channel
{{Authority control Hospital buildings completed in 1956 Hospitals in Apulia Hospitals established in 1956 San Giovanni Rotondo