Carbonyl cyanide-''p''-trifluoromethoxyphenylhydrazone (FCCP) is an

ionophore In chemistry, an ionophore () is a chemical species that reversibly binds ions. Many ionophores are lipid-soluble entities that transport ions across the cell membrane. Ionophores catalyze ion transport across hydrophobic membranes, such as liq ...

that is a mobile ion carrier. It is referred to as an uncoupling agent because it disrupts ATP synthesis by transporting

hydrogen ions A hydrogen ion is created when a hydrogen atom loses or gains an electron. A positively charged hydrogen ion (or proton) can readily combine with other particles and therefore is only seen isolated when it is in a gaseous state or a nearly particle ...

through the mitochondrial membrane before they can be used to provide the energy for oxidative phosphorylation. It is a nitrile and

hydrazone Hydrazones are a class of organic compounds with the structure . They are related to ketones and aldehydes by the replacement of the oxygen =O with the = functional group. They are formed usually by the action of hydrazine on ketones or aldehyde ...

. FCCP was first described in 1962 by Heytler.

References

{{reflist Ionophores Nitriles Trifluoromethyl ethers Uncoupling agents Hydrazones

See also

References