Canine Coronavirus HuPn-2018
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Canine coronavirus HuPn-2018, or CCoV-HuPn-2018, is a virus first discovered in a surveillance study in
Sarawak Sarawak (; ) is a States and federal territories of Malaysia, state of Malaysia. The largest among the 13 states, with an area almost equal to that of Peninsular Malaysia, Sarawak is located in northwest Borneo Island, and is bordered by the M ...
,
Malaysia Malaysia ( ; ) is a country in Southeast Asia. The federation, federal constitutional monarchy consists of States and federal territories of Malaysia, thirteen states and three federal territories, separated by the South China Sea into two r ...
, in hospitalized human pneumonia patients. It may be the eighth coronavirus known to cause disease in humans, but no human-to-human transmission has been seen. This is a canine-feline recombinant
alphacoronavirus Alphacoronaviruses (Alpha-CoV) are members of the first of the four genera (''Alpha''-, '' Beta-'', '' Gamma-'', and '' Delta-'') of coronaviruses. They are positive-sense, single-stranded RNA viruses that infect mammals, including humans. They ...
(
genotype The genotype of an organism is its complete set of genetic material. Genotype can also be used to refer to the alleles or variants an individual carries in a particular gene or genetic location. The number of alleles an individual can have in a ...
II) related to the CCoV-II strain of ''
Alphacoronavirus 1 ''Alphacoronavirus 1'' is a species of coronavirus that infects cats, dogs and pigs. It includes the virus strains feline coronavirus, canine coronavirus, and transmissible gastroenteritis virus.' It is an Viral envelope, enveloped, positive-s ...
'' with part of the FCoV in S2 domain and a specific 12
amino acid Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha am ...
s deletion in the N protein.


References

{{Coronaviridae Animal virology Alphacoronaviruses Zoonoses