Rab proteins geranylgeranyltransferase component A 2 is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''CHML''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II.
Interactions
CHML (gene) has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
RAB1A
Ras-related protein Rab-1A is a protein that in humans is encoded by the ''RAB1A'' gene.
Interactions
RAB1A has been shown to interact with:
* CHML,
* GOLGA2,
* GOLGA5,
* MICAL1
* RABAC1
''RABAC1'' is a gene that in humans encodes the pr ...
and
RAB5A
Ras-related protein Rab-5A is a protein that in humans is encoded by the ''RAB5A'' gene.
Function
RAB5A localizes to early endosomes where it is involved in the recruitment of RAB7A and the maturation of these compartments to late endosomes. I ...
.
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References
Further reading
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External links
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