Cell division control protein 6 homolog is a
protein that in humans is encoded by the ''CDC6''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ...
.
The protein encoded by this gene is highly similar to
Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in the cell nucleus during
cell cycle
The cell cycle, or cell-division cycle, is the series of events that take place in a cell that cause it to divide into two daughter cells. These events include the duplication of its DNA (DNA replication) and some of its organelles, and subs ...
phase G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during the cell cycle is regulated through its phosphorylation by
cyclin-dependent kinase
Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. They a ...
s. Transcription of this protein was reported to be regulated in response to mitogenic signals through a transcriptional control mechanism involving E2F proteins.
Interactions
CDC6 has been shown to
interact
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with
ORC1L,
ORC2L
Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans.
Function
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA rep ...
,
Cyclin A2
Cyclin-A2 is a protein that in humans is encoded by the ''CCNA2'' gene. It is one of the two types of cyclin A: cyclin A1 is expressed during meiosis and embryogenesis while cyclin A2 is expressed in dividing somatic cells.
Function
Cyclin A2 ...
,MCM7
DNA replication licensing factor MCM7 is a protein that in humans is encoded by the ''MCM7'' gene.
Function
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the in ...
[ and PSKH1.][
]
See also
* Cdc6, the family of orthologs in eukaryotes
References
Further reading
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External links
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{{DNA replication