Cannabidivarin (CBDV, GWP42006) is a non-
psychoactive
A psychoactive drug, psychopharmaceutical, psychoactive agent or psychotropic drug is a chemical substance, that changes functions of the nervous system, and results in alterations in perception, mood, consciousness, cognition or behavior.
Th ...
cannabinoid
Cannabinoids () are several structural classes of compounds found in the cannabis plant primarily and most animal organisms (although insects lack such receptors) or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid te ...
found in ''
Cannabis
''Cannabis'' () is a genus of flowering plants in the family Cannabaceae. The number of species within the genus is disputed. Three species may be recognized: ''Cannabis sativa'', '' C. indica'', and '' C. ruderalis''. Alternativel ...
''. It is a
homolog (chemistry)
In chemistry, homology is the appearance of homologues. A homologue (also spelled as homolog) is a compound belonging to a series of compounds differing from each other by a repeating unit, such as a methylene bridge −−, a peptide residue, e ...
of
cannabidiol
Cannabidiol (CBD) is a phytocannabinoid discovered in 1940. It is one of 113 identified cannabinoids in cannabis plants, along with tetrahydrocannabinol (THC), and accounts for up to 40% of the plant's extract. , clinical research on CBD incl ...
(CBD), with the
side-chain shortened by two
methylene bridges (CH
2 units).
Although cannabidivarin (CBDV) is usually a minor constituent of the cannabinoid profile, enhanced levels of CBDV have been reported in feral populations of ''C. indica'' ( = ''C. sativa'' ssp. ''indica'' var. ''kafiristanica'') from northwest
India, and in
hashish
Hashish ( ar, حشيش, ()), also known as hash, "dry herb, hay" is a drug made by compressing and processing parts of the cannabis plant, typically focusing on flowering buds (female flowers) containing the most trichomes. European Monitoring ...
from
Nepal.
CBDV has anticonvulsant effects. It was identified for the first time in 1969 by Vollner et al.
Similarly to CBD, it has seven double bond isomers and 30 stereoisomers (see:
Cannabidiol#Isomerism). It is not scheduled by
Convention on Psychotropic Substances
The Convention on Psychotropic Substances of 1971 is a United Nations treaty designed to control psychoactive drugs such as amphetamine-type stimulants, barbiturates, benzodiazepines, and psychedelics signed in Vienna, Austria on 21 February 19 ...
. It is being actively developed by
GW Pharmaceuticals
GW Pharmaceuticals is a British pharmaceutics company known for its multiple sclerosis treatment product nabiximols (brand name, Sativex) which was the first natural cannabis plant derivative to gain market approval in any country. Another cannab ...
(as GWP42006)
because of a demonstrated neurochemical pathway for previously observed anti-epileptic and anti-convulsive action. GW has begun a phase 2 trial for adult
epilepsy, and is to begin trials of this CBDV product in children in 2016 in
Australia.
See also
*
List of investigational analgesics
This is a list of investigational analgesics, or analgesics that are currently under development for clinical use but are not yet approved. ''Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in pare ...
References
External links
ErowidCompounds found in ''Cannabis sativa''
CBDV(in German)
Cannabidivarin
Phytocannabinoids
Natural phenols
2,6-Dihydroxybiphenyls
Cyclohexenes
{{cannabinoid-stub