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Cyantraniliprole is an insecticide of the
ryanoid Ryanoids are a class of insecticides which share the same mechanism of action as the alkaloid ryanodine Ryanodine is a poisonous diterpenoid found in the South American plant ''Ryania speciosa'' (Salicaceae). It was originally used as an insectici ...
class, specifically a diamide insecticide (IRAC
MoA Moa are extinct giant flightless birds native to New Zealand. The term has also come to be used for chicken in many Polynesian cultures and is found in the names of many chicken recipes, such as Kale moa and Moa Samoa. Moa or MOA may also refe ...
group 28). It is approved for use in the
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,
Canada Canada is a country in North America. Its ten provinces and three territories extend from the Atlantic Ocean to the Pacific Ocean and northward into the Arctic Ocean, covering over , making it the world's second-largest country by tot ...
, China, and
India India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the so ...
. Because of its uncommon
mechanism of action In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. A mechanism of action usually includes mention of the specific molecular targ ...
as a ryanoid, it has activity against pests such as ''
Diaphorina citri ''Diaphorina citri'', the Asian citrus psyllid, is a sap-sucking, hemipteran bug in the family Psyllidae. It is one of two confirmed vectors of citrus greening disease. It has a wide distribution in southern Asia and has spread to other citrus g ...
'' that have developed resistance to other classes of insecticides. Cyantraniliprole is highly toxic to bees, which resulted in registration of its use as a pesticide being delayed in the USA.


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https://biologicaldiversity.org/w/news/press-releases/legal-victory-court-orders-epa-to-protect-endangered-wildlife-from-toxic-pesticide-2022-11-22/ This insecticide is highly toxic to bees and is under review by the EPA for appropriate restrictions to use. “Today’s decision is a vital victory for endangered species and the planet,” said George Kimbrell, the Center for Food Safety’s legal director and co-petitioner in the case. “As EPA has proven over and over with pesticides, the only way the agency will do its job is when forced by a court.” Even after finding that cyantraniliprole is “highly or very highly toxic” to hundreds of endangered species the agency authorized widespread uses of it in both agricultural and urban areas without measures to safeguard protected species. In addition to being a highly toxic systemic insecticide, cyantraniliprole remains in the environment for years after use. The EPA’s risk assessment found the pesticide has a half-life of 1,327 days in the soil, meaning half of the pesticide remains in the soil for more than three and a half years after it is applied. Cyantraniliprole use has increased exponentially since the agency registered it in 2014, according to research by the U.S. Geological Survey. In several other cases when the EPA has been forced to analyze pesticides’ impacts to endangered species the agency has found widespread harm. {{insecticides Insecticides Benzamides Nitriles Pyridines Pyrazoles