Critical Assessment of PRediction of Interactions (CAPRI) is a community-wide experiment in modelling the
molecular structure
Molecular geometry is the three-dimensional arrangement of the atoms that constitute a molecule. It includes the general shape of the molecule as well as bond lengths, bond angles, torsional angles and any other geometrical parameters that determ ...
of
protein complexes, otherwise known as
protein–protein docking
Macromolecular docking is the computational modelling of the quaternary structure of complexes formed by two or more interacting biological macromolecules. Protein–protein complexes are the most commonly attempted targets of such modelling, fol ...
.
The CAPRI
is an ongoing series of events in which researchers throughout the community attempt to dock the same proteins, as provided by the assessors. Rounds take place about every six months. Each round contains between one and six target protein–protein complexes whose structures have been recently determined experimentally. The coordinates and are held privately by the assessors, with the co-operation of the
structural biologists who determined them. The CAPRI experiment is
double-blind, in the sense that the submitters do not know the solved structure, and the assessors do not know the correspondence between a submission and the identity of its creator.
See also
*
(CASP) — a similar exercise in the field of protein structure prediction
*
Critical Assessment of Functional Annotation (CAFA)
References
External links
*
CAPRI or: What is the State of Protein-Protein Docking?
List of predictions servers participating in CAPRI
ClusProGRAMM-XFireDockHADDOCK
— High-Ambiguity-Driven protein–protein DOCKing
pyDockWEB
— Structural prediction of protein–protein interactions
PatchDockSmoothDock3D-Garden
— Global and Restrained Docking Exploration Nexus
SPIDER
- Scoring Protein-Protein Interactions
Molecular modelling
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