Crichton-Browne sign is a

clinical sign Signs and symptoms are the observed or detectable signs, and experienced symptoms of an illness, injury, or condition. A sign for example may be a higher or lower temperature than normal, raised or lowered blood pressure or an abnormality showin ...

in which there is twitching of the outer margins of the eyes and mouth. It is an early sign of

general paralysis of the insane General paresis, also known as general paralysis of the insane (GPI), paralytic dementia, or syphilitic paresis is a severe neuropsychiatric disorder, classified as an organic mental disorder and is caused by late-stage syphilis and the chro ...

. The sign was described by Sir James Crichton-Browne.

References

{{med-sign-stub Medical signs