The conformational dynamics data bank (CDDB) is a
database
In computing, a database is an organized collection of data stored and accessed electronically. Small databases can be stored on a file system, while large databases are hosted on computer clusters or cloud storage. The design of databases sp ...
about
conformational dynamics of
heavy proteins and
protein assemblies. The CDDB is useful when used alongside static structural data to aid research into
protein function. It is also helpful in identifying protein assemblies that are essential to
cell function
Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living and ...
.
Analysis is carried out by
coarse-grained computation of the structures present in the
electron microscopy data bank The EM Data Bank or Electron Microscopy Data Bank (EMDB) collects 3D EM maps and associated experimental data determined using electron microscopy of biological specimens. It was established in 2002 at the MSD/PDBe group of the European Bioinformat ...
(EMDB). This analysis shows
equilibrium thermal fluctuations and
elastic strain energy distributions, which allows for identification of rigid and flexible protein domains. The results also provide information on correlations in
molecular motions which can be used to identify molecular regions that are highly coupled dynamically.
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References
External links
Data bank website
Biological databases
Protein structure
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