Common Fumitory
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''Fumaria officinalis'', the common fumitory, drug fumitory or earth smoke, is a herbaceous annual
flowering plant Flowering plants are plants that bear flowers and fruits, and form the clade Angiospermae (), commonly called angiosperms. The term "angiosperm" is derived from the Greek words ('container, vessel') and ('seed'), and refers to those plants th ...
in the poppy family
Papaveraceae The Papaveraceae are an economically important family of about 42 genera and approximately 775 known species of flowering plants in the order Ranunculales, informally known as the poppy family. The family is cosmopolitan, occurring in temperat ...
. It is the most common species of the genus ''
Fumaria ''Fumaria'' (fumitory or fumewort, from Latin ', "smoke of the earth") is a genus of about 60 species of annual flowering plants in the family Papaveraceae. The genus is native to Europe, Africa and Asia, most diverse in the Mediterranean regi ...
'' in
Western Western may refer to: Places *Western, Nebraska, a village in the US *Western, New York, a town in the US *Western Creek, Tasmania, a locality in Australia *Western Junction, Tasmania, a locality in Australia *Western world, countries that id ...
and
Central Europe Central Europe is an area of Europe between Western Europe and Eastern Europe, based on a common historical, social and cultural identity. The Thirty Years' War (1618–1648) between Catholicism and Protestantism significantly shaped the area' ...
.


Description

It is an
herbaceous Herbaceous plants are vascular plants that have no persistent woody stems above ground. This broad category of plants includes many perennials, and nearly all annuals and biennials. Definitions of "herb" and "herbaceous" The fourth edition of t ...
annual plant An annual plant is a plant that completes its life cycle, from germination to the production of seeds, within one growing season, and then dies. The length of growing seasons and period in which they take place vary according to geographical ...
that grows weakly erect and scrambling, with stalks about long. It has slender green leaves. Its pink flowers appear from April to October in the northern hemisphere, or May to September in the UK. They are two lipped and spurred, with
sepal A sepal () is a part of the flower of angiosperms (flowering plants). Usually green, sepals typically function as protection for the flower in bud, and often as support for the petals when in bloom., p. 106 The term ''sepalum'' was coined b ...
s running a quarter the length of the petals. The plant commonly has more than 20 and up to 60 flowers per spike. The fruit is an
achene An achene (; ), also sometimes called akene and occasionally achenium or achenocarp, is a type of simple dry fruit produced by many species of flowering plants. Achenes are monocarpellate (formed from one carpel) and indehiscent (they do not ope ...
containing one seed. It is approximately globular, slightly wider than high and with an apical notch. It contains
alkaloid Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar ...
s,
potassium salt In chemistry, a salt is a chemical compound consisting of an ionic assembly of positively charged cations and negatively charged anions, which results in a compound with no net electric charge. A common example is table salt, with positively ch ...
s, and
tannin Tannins (or tannoids) are a class of astringent, polyphenolic biomolecules that bind to and precipitate proteins and various other organic compounds including amino acids and alkaloids. The term ''tannin'' (from Anglo-Norman ''tanner'', ...
s and is also a source of
fumaric acid Fumaric acid is an organic compound with the formula HO2CCH=CHCO2H. A white solid, fumaric acid occurs widely in nature. It has a fruit-like taste and has been used as a food additive. Its E number is E297. The salts and esters are known as fu ...
.


Taxonomy

It was first formally described by the Swedish botanist
Carl Linnaeus Carl Linnaeus (; 23 May 1707 – 10 January 1778), also known after his ennoblement in 1761 as Carl von Linné Blunt (2004), p. 171. (), was a Swedish botanist, zoologist, taxonomist, and physician who formalised binomial nomenclature, the ...
in his seminal publication '
Species Plantarum ' (Latin for "The Species of Plants") is a book by Carl Linnaeus, originally published in 1753, which lists every species of plant known at the time, classified into genera. It is the first work to consistently apply binomial names and was the ...
' on page 700, in 1753. There are 2 known subspecies: * ''Fumaria officinalis'' subsp. ''cilicica'' (Hausskn.) Lidén * ''Fumaria officinalis'' subsp. ''wirtgenii'' (Koch) Arcang.


Etymology

The "smoky" or "fumy" origin of its name comes from the translucent color of its flowers, giving them the appearance of smoke or of hanging in smoke, and the slightly gray-blue haze color of its foliage, also resembling smoke coming from the ground, especially after morning dew. The plant was already called ' (smoke of the earth) in the early 13th century, and two thousand years ago,
Dioscorides Pedanius Dioscorides ( grc-gre, Πεδάνιος Διοσκουρίδης, ; 40–90 AD), “the father of pharmacognosy”, was a Greek physician, pharmacologist, botanist, and author of ''De materia medica'' (, On Medical Material) —a 5-vol ...
wrote in ' () and
Pliny the Elder Gaius Plinius Secundus (AD 23/2479), called Pliny the Elder (), was a Roman author, naturalist and natural philosopher, and naval and army commander of the early Roman Empire, and a friend of the emperor Vespasian. He wrote the encyclopedic '' ...
in ' that rubbing the eyes with the sap or latex of the plant causes tears, like acrid smoke (') does to the eyes. Its Greek name is ''kapnos'' (', for ''smoke'') and the name ''fumewort'' now applies mostly to the genus ''
Corydalis ''Corydalis'' (from Greek ''korydalís'' "crested lark") is a genus of about 470 species of annual and perennial herbaceous plants in the family Papaveraceae, native to the temperate Northern Hemisphere and the high mountains of tropical eastern ...
'', especially the similar looking ''
Corydalis solida ''Corydalis solida'', fumewort or bird-in-a-bush, is a species of flowering plant in the family Papaveraceae, native to moist, shady habitats in northern Europe and Asia. Growing to , it is a spring ephemeral, with foliage that appears in sprin ...
'' (formerly ''Fumaria bulbosa''), which was thought to belong to the same genus as fumitory.
,
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and
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. Within Western Asia it is found in the
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,
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and
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. In middle Europe, it is in
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and
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. In northern Europe, in
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and
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. In southeastern Europe, within
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France France (), officially the French Republic ( ), is a country primarily located in Western Europe. It also comprises of Overseas France, overseas regions and territories in the Americas and the Atlantic Ocean, Atlantic, Pacific Ocean, Pac ...
,
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.


Herbalism

Usage of this plant as medicine began in Europe in the late Middle Ages, although it was known since antiquity. In 17th century Europe it was publicised as good for the eyes (due to remarks by
Pliny Pliny may refer to: People * Pliny the Elder (23–79 CE), ancient Roman nobleman, scientist, historian, and author of ''Naturalis Historia'' (''Pliny's Natural History'') * Pliny the Younger (died 113), ancient Roman statesman, orator, w ...
and later
Olivier de Serres Olivier de Serres (; 1539–1619) was a French author and soil scientist whose '' Théâtre d'Agriculture'' (1600) was the accepted textbook of French agriculture in the 17th century. Biography Serres was born in 1539 at Villeneuve-de-Berg, ...
that rubbing its juice in one's eyes caused excessive tearing).Howard, Michael. ''Traditional Folk Remedies'' (century, 1987). pp142-3. The most common traditional uses were as a digestive aid and a
diuretic A diuretic () is any substance that promotes diuresis, the increased production of urine. This includes forced diuresis. A diuretic tablet is sometimes colloquially called a water tablet. There are several categories of diuretics. All diuretics in ...
, but various folk traditions throughout Europe ascribed to it a multitude of uses: constipation,
cystitis A urinary tract infection (UTI) is an infection that affects part of the urinary tract. When it affects the lower urinary tract it is known as a bladder infection (cystitis) and when it affects the upper urinary tract it is known as a kidney ...
,
arteriosclerosis Arteriosclerosis is the thickening, hardening, and loss of elasticity of the walls of Artery, arteries. This process gradually restricts the blood flow to one's organs and tissues and can lead to severe health risks brought on by atherosclerosis ...
,
rheumatism Rheumatism or rheumatic disorders are conditions causing chronic, often intermittent pain affecting the joints or connective tissue. Rheumatism does not designate any specific disorder, but covers at least 200 different conditions, including art ...
,
arthritis Arthritis is a term often used to mean any disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints. In som ...
, as a blood purifier, for
hypoglycaemia Hypoglycemia, also called low blood sugar, is a fall in blood sugar to levels below normal, typically below 70 mg/dL (3.9 mmol/L). Whipple's triad is used to properly identify hypoglycemic episodes. It is defined as blood glucose belo ...
, infections, and possibly to cleanse the kidneys. In
Sicily (man) it, Siciliana (woman) , population_note = , population_blank1_title = , population_blank1 = , demographics_type1 = Ethnicity , demographics1_footnotes = , demographi ...
and perhaps elsewhere it was used to treat skin blemishes, and in
Britain Britain most often refers to: * The United Kingdom, a sovereign state in Europe comprising the island of Great Britain, the north-eastern part of the island of Ireland and many smaller islands * Great Britain, the largest island in the United King ...
into the modern era as an eyewash to treat
conjunctivitis Conjunctivitis, also known as pink eye, is inflammation of the conjunctiva, outermost layer of the white part of the eye and the inner surface of the eyelid. It makes the eye appear pink or reddish. Pain, burning, scratchiness, or itchiness may ...
. Since 1963 it has been marketed as a herbal medicine in
France France (), officially the French Republic ( ), is a country primarily located in Western Europe. It also comprises of Overseas France, overseas regions and territories in the Americas and the Atlantic Ocean, Atlantic, Pacific Ocean, Pac ...
. As of 2011 herbal products made from this plant are legally sold in various forms in
Austria Austria, , bar, Östareich officially the Republic of Austria, is a country in the southern part of Central Europe, lying in the Eastern Alps. It is a federation of nine states, one of which is the capital, Vienna, the most populous ...
,
Germany Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ...
, France and
Spain , image_flag = Bandera de España.svg , image_coat = Escudo de España (mazonado).svg , national_motto = ''Plus ultra'' (Latin)(English: "Further Beyond") , national_anthem = (English: "Royal March") , i ...
. Products may be legally sold in the British market (it is on the British
General Sales List Over-the-counter (OTC) drugs are medication, medicines sold directly to a consumer without a requirement for a medical prescription, prescription from a healthcare professional, as opposed to prescription drugs, which may be supplied only to co ...
), although no products were sold there as of 2011. In the European Union as a whole marketing of the plant is not necessarily legal: it has been rejected from the Community List by the
Committee on Herbal Medicinal Products The Committee on Herbal Medicinal Products (HMPC), is the European Medicines Agency's committee responsible for elaborating the agency's opinions on herbal medicines. Role HMPC aims at assisting in the harmonization of procedures and provisions con ...
due to the lack of toxicology studies. Products in France and Spain are marketed as a digestive (said to work by increasing bile flow), in Austria it is sold for treatment of
dyskinesia Dyskinesia refers to a category of movement disorders that are characterized by involuntary muscle movements, including movements similar to tics or chorea and diminished voluntary movements. Dyskinesia can be anything from a slight tremor of t ...
of the
biliary duct A bile duct is any of a number of long tube-like structures that carry bile, and is present in most vertebrates. Bile is required for the digestion of food and is secreted by the liver into passages that carry bile toward the hepatic duct. It ...
, in Germany it is simply sold as an herbal tea. There is some evidence from animal models that it modifies abnormal bile flow, although it has no effect on normal choleresis. An
antispasmodic An antispasmodic (synonym: spasmolytic) is a pharmaceutical drug or other agent that suppresses muscle spasms. Smooth muscle spasm One type of antispasmodics is used for smooth muscle relaxation, especially in tubular organs of the gastrointesti ...
effect on the upper digestive tract
in vitro ''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology an ...
and in animal studies is considered sufficiently documented. The efficacy of the herbal products in humans is considered plausible but yet unproven in clinical studies. Numerous clinical studies in its amphocholeretic uses in humans have demonstrated the tolerability and safety of dosages used, but there has only been one small double-blind trial with placebos which was inconclusive regarding efficacy. A larger double-blind trial with
placebo A placebo ( ) is a substance or treatment which is designed to have no therapeutic value. Common placebos include inert tablets (like sugar pills), inert injections (like Saline (medicine), saline), sham surgery, and other procedures. In general ...
s investigating and comparing its use in the treatment of pain and distension due to
irritable bowel syndrome Irritable bowel syndrome (IBS) is a "disorder of gut-brain interaction" characterized by a group of symptoms that commonly include abdominal pain and or abdominal bloating and changes in the consistency of bowel movements. These symptoms may ...
with ''Curcuma'' demonstrated no statistically significant differences between treatment groups (although use of either herb appeared to slightly worsen either distension or pain respectively, compared to placebo use). A number of other potential effects or uses for the plant and its major alkaloid
protopine Protopine is an alkaloid occurring in opium poppy, ''Corydalis'' tubers and other plants of the family papaveraceae, like ''Fumaria officinalis''. Protopine is metabolically derived from the benzylisoquinoline alkaloid ''(S)''-Reticuline through a ...
have been researched in vitro or in animal models. Howard (1987) warns that fumitory is
poison Poison is a chemical substance that has a detrimental effect to life. The term is used in a wide range of scientific fields and industries, where it is often specifically defined. It may also be applied colloquially or figuratively, with a broa ...
ous and should only be used "under the direction of a medical herbalist", but in Europe, no safety problems with its use have been recorded as of 2011. Large doses of protopine in animal models causes excitation and convulsions. Thorough toxicological research on this plant has not been conducted as of 2011. There have been no studies on its safety or effect on pregnant woman, children or elderly.


Chemical constituents

The plant contains
isoquinoline Isoquinoline is a heterocyclic aromatic organic compound. It is a structural isomer of quinoline. Isoquinoline and quinoline are benzopyridines, which are composed of a benzene ring fused to a pyridine ring. In a broader sense, the term isoquin ...
alkaloids
protopine Protopine is an alkaloid occurring in opium poppy, ''Corydalis'' tubers and other plants of the family papaveraceae, like ''Fumaria officinalis''. Protopine is metabolically derived from the benzylisoquinoline alkaloid ''(S)''-Reticuline through a ...
and
allocryptopine Allocryptopine is a bioactive alkaloid found in plants of the Papaveraceae family, including '' Glaucium arabicum'' ''Argemone mexicana'' , '' Eschscholtzia'' , '' Corydalis'' , ''Fumaria ''Fumaria'' (fumitory or fumewort, from Latin ', "sm ...
. Both protopine and allocryptopine increased
CYP1A1 Cytochrome P450, family 1, subfamily A, polypeptide 1 is a protein that in humans is encoded by the ''CYP1A1'' gene. The protein is a member of the cytochrome P450 superfamily of enzymes. Function Metabolism of xenobiotics and drugs CYP1A1 ...
and
CYP1A2 Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the human body. In humans, the CYP1A2 enzyme is encoded by the ''CYP1A2'' gene. Function ...
mRNA In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of Protein biosynthesis, synthesizing a protein. mRNA is ...
levels in human
hepatocyte A hepatocyte is a cell of the main parenchymal tissue of the liver. Hepatocytes make up 80% of the liver's mass. These cells are involved in: * Protein synthesis * Protein storage * Transformation of carbohydrates * Synthesis of cholesterol, ...
cells. The use of products containing protopine and/or allocryptopine may be considered safe in terms of possible induction of
CYP1A Cytochrome P450, family 1, subfamily A, polypeptide 1 is a protein that in humans is encoded by the ''CYP1A1'' gene. The protein is a member of the cytochrome P450 superfamily of enzymes. Function Metabolism of xenobiotics and drugs CYP1A1 ...
enzymes.


References

{{Taxonbar, from=Q157618
officinalis ''Officinalis'', or ''officinale'', is a Medieval Latin epithet denoting organisms—mainly plants—with uses in medicine, herbalism and cookery. It commonly occurs as a specific epithet, the second term of a two-part botanical name. ''Officinali ...
Flora of North Africa Flora of Europe Flora of the United Kingdom Medicinal plants of Europe Plants described in 1753 Taxa named by Carl Linnaeus