The Collaborative Computational Project Number 4 in

protein crystallography X-ray crystallography is the experimental science determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to diffract into many specific directions. By measuring the angles ...

(CCP4) was set up in 1979 in the

United Kingdom The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Europe, off the north-western coast of the continental mainland. It comprises England, Scotland, Wales and North ...

to support collaboration between researchers working in software development and assemble a comprehensive collection of software for

structural biology Structural biology is a field that is many centuries old which, and as defined by the Journal of Structural Biology, deals with structural analysis of living material (formed, composed of, and/or maintained and refined by living cells) at every le ...

. The CCP4 core team is located at the Research Complex at Harwell (RCaH) at

Rutherford Appleton Laboratory The Rutherford Appleton Laboratory (RAL) is one of the national scientific research laboratories in the UK operated by the Science and Technology Facilities Council (STFC). It began as the Rutherford High Energy Laboratory, merged with the Atlas ...

(RAL) in

Didcot Didcot ( ) is a railway town and civil parish in the ceremonial county of Oxfordshire and the historic county of Berkshire. Didcot is south of Oxford, east of Wantage and north west of Reading. The town is noted for its railway heritage, Di ...

, near Oxford, UK. CCP4 was originally supported by the UK

Science and Engineering Research Council The Science and Engineering Research Council (SERC) and its predecessor the Science Research Council (SRC) were the UK agencies in charge of publicly funded scientific and engineering research activities, including astronomy, biotechnology and bi ...

(SERC), and is now supported by the

Biotechnology and Biological Sciences Research Council Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation, is a non-departmental public body (NDPB), and is the largest UK public funder of non-medical bioscience. It predominantly funds scientific rese ...

(BBSRC). The project is coordinated at CCLRC Daresbury Laboratory. The results of this effort gave rise to the CCP4 program suite,M.D. Winn, C.C. Ballard, K.D. Cowtan, E.J. Dodson, P. Emsley, P.R. Evans, R.M. Keegan, E.B. Krissinel, A.G.W. Leslie, A. McCoy, S.J. McNicholas, G.N. Murshudov, N.S. Pannu, E.A. Potterton, H.R. Powell, R.J. Read, A. Vagin, K.S. Wilson (2011) ''Overview of the CCP4 suite and current developments'' Acta Crystallogr. D67, 235-24

/ref> which is now distributed to academic and commercial users worldwide.

Projects

*CCP4i – CCP4 Graphical User Interface *CCP4MG – CCP4 Molecular Graphics Project * Coot (software), Coot – Graphical Model Building *HAPPy – automated experimental phasing *MrBUMP – automated Molecular Replacement *PISA – Protein Interfaces, Surfaces and Assemblies *MOSFLM GUI – building a modern interface to MOSFLM

External links

*
CCP4 Documentation wiki
— concentrates only on CCP4
CCP4 Community wiki
— general X-ray crystallography topics related to CCP4

References

{{Crystallography Crystallography Medical Research Council (United Kingdom) Science and technology in Oxfordshire Vale of White Horse

Projects

See also

External links

References