Cleveland, Painesville and Ashtabula Railroad may refer to:
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Cleveland, Painesville and Ashtabula Railroad (1848–1869)
The Cleveland, Painesville and Ashtabula Railroad (CP&A), also known informally as the Cleveland and Erie Railroad, the Cleveland and Buffalo Railroad, and the Lake Shore Railroad, was a railway which ran from Cleveland, Ohio, to the Ohio-Pennsyl ...
, predecessor of the Lake Shore and Michigan Southern Railway (New York Central system)
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Cleveland, Painesville and Ashtabula Railroad (1879–1886), predecessor of the New York, Chicago and St. Louis Railroad (Nickel Plate)
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