Clear cell papillary renal cell carcinoma (CCPRCC) is a rare subtype of renal cell carcinoma (RCC) that has microscopic morphologic features of

papillary renal cell carcinoma Papillary renal cell carcinoma (PRCC) is a malignant, heterogeneous tumor originating from renal tubular epithelial cells of the kidney, which comprises approximately 10-15% of all kidney neoplasms. Based on its morphological features, PRCC can be ...

and

clear cell renal cell carcinoma Clear-cell renal-cell carcinoma (CCRCC) is a type of renal-cell carcinoma. Genetics Cytogenetics * Alterations of chromosome 3p segments occurs in 70–90% of CCRCCs * Inactivation of von Hippel–Lindau disease ( VHL) gene by gene mutation ...

, yet is pathologically distinct based on molecular changes and

immunohistochemistry Immunohistochemistry (IHC) is the most common application of immunostaining. It involves the process of selectively identifying antigens (proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to an ...

Pathology

CCPRCC classically has apical nuclei, i.e. the nucleus is adjacent to the luminal aspect. In most glandular structures the nuclei are usually basally located, i.e. in the cytoplasm adjacent to the

basement membrane The basement membrane is a thin, pliable sheet-like type of extracellular matrix that provides cell and tissue support and acts as a platform for complex signalling. The basement membrane sits between Epithelium, epithelial tissues including mesot ...

. They typically

stain A stain is a discoloration that can be clearly distinguished from the surface, material, or medium it is found upon. They are caused by the chemical or physical interaction of two dissimilar materials. Accidental staining may make materials app ...

with CK7 and do not stain with TFE3 and

AMACR α-Methylacyl-CoA racemase (AMACR, ) is an enzyme that in humans is encoded by the ''AMACR'' gene. AMACR catalysis, catalyzes the following chemical reaction: :(2''R'')-2-methylacyl-CoA \rightleftharpoons (2''S'')-2-methylacyl-CoA In mammalian c ...

References

{{Tumor morphology Kidney cancer

Pathology

See also

References