Clay Margrave Armstrong (born 1934) is an American physiologist and a former student of

Andrew Fielding Huxley Sir Andrew Fielding Huxley (22 November 191730 May 2012) was an English physiologist and biophysicist. He was born into the prominent Huxley family. After leaving Westminster School in central London, he went to Trinity College, Cambridge on ...

. Armstrong received his MD from

Washington University School of Medicine Washington University School of Medicine (WUSM) is the medical school of Washington University in St. Louis in St. Louis, Missouri. Founded in 1891, the School of Medicine has 1,260 students, 604 of which are pursuing a medical degree with or ...

in 1960. He is currently emeritus professor of Physiology at the

University of Pennsylvania The University of Pennsylvania (also known as Penn or UPenn) is a private research university in Philadelphia. It is the fourth-oldest institution of higher education in the United States and is ranked among the highest-regarded universitie ...

. He has also held professorial appointments at

Duke University Duke University is a private research university in Durham, North Carolina. Founded by Methodists and Quakers in the present-day city of Trinity in 1838, the school moved to Durham in 1892. In 1924, tobacco and electric power industrialist James ...

and the University of Rochester. Armstrong was awarded the Louisa Gross Horwitz Prize from Columbia University in 1996, and the Albert Lasker Award for Basic Medical Research (shared with Bertil Hille and Roderick MacKinnon) in 1999, for his seminal contributions to our understanding of the functions of ion channel proteins in nerve cells. Armstrong was elected to the National Academy of Sciences in 1987, and was elected as a Fellow of the American Academy of Arts and Sciences in 1999. He won the 2001 Gairdner Foundation International Award. Armstrong is married to noted scientist Clara Franzini-Armstrong.

Ideas and influence

Much of the current understanding of ion channel structure and function can be attributed to the notion proposed by Clay Armstrong (with Bertil Hille). Armstrong provided the first general description of the K+ ion channel pore, including the fundamental ideas of a selectivity filter that can allow the rapid flow of K+ while excluding the flow of Na+ across the cell membrane; a wide inner vestibule; and a molecular gating element at the cytoplasmic side of the channel that controls the flow of ions through the pore. In addition, Armstrong's studies (with Francisco Bezanilla) that described the first measurement of charge movement associated with the activation of Na+-selective ion channels laid the groundwork for the current understanding of the molecular basis of electrical signaling in nerve and muscle cells. A consistent feature of Armstrong's contributions is the quantitative nature of his work, combined with clear and concise descriptions of the underlying mechanism.

References

{{DEFAULTSORT:Armstrong, Clay American physiologists University of Pennsylvania faculty Recipients of the Albert Lasker Award for Basic Medical Research Living people 1934 births Fellows of the American Academy of Arts and Sciences Members of the United States National Academy of Sciences Electrophysiologists Members of the National Academy of Medicine