Class II PI 3-kinases are a subgroup of the enzyme family,

phosphoinositide 3-kinase Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which i ...

that share a common protein domain structure, substrate specificity and method of activation. Class II PI 3-kinases were the most recently identified class of PI 3-kinases. There are three class II PI 3-kinase isoforms expressed in mammalian cells; *PI3K-C2α encoded by the

PIK3C2A Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide is an enzyme that in humans is encoded by the ''PIK3C2A'' gene. The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases p ...

gene *PI3K-C2β encoded by the PIK3C2B gene *PI3K-C2γ encoded by the

PIK3C2G Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide is an enzyme that in humans is encoded by the ''PIK3C2G'' gene. The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases ...

gene

References

*Stein RC (2001) Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment ''Endocr Relat Cancer'' 8:237-24

*Foster FM, Traer CJ, Abraham SM, and Fry MJ (2003) The phosphoinositide (PI) 3-kinase family ''J Cell Sci'' 116:3037-304

*Vanhaesebroeck B, Waterfield MD.(1999) Signaling by distinct classes of phosphoinositide 3-kinases. ''Exp Cell Res.'' 253(1):239-5

EC 2.7.1 {{Cell-biology-stub

See also

References