The
enzyme citrate (''pro''-3''S'')-lyase ()
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction
:citrate
acetate + oxaloacetate
This enzyme belongs to the family of
lyase
In biochemistry, a lyase is an enzyme that catalyzes the breaking (an elimination reaction) of various chemical bonds by means other than hydrolysis (a substitution reaction) and oxidation, often forming a new double bond or a new ring structure. ...
s, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The
systematic name of this enzyme class is citrate oxaloacetate-lyase (forming acetate from the pro-S carboxymethyl group of citrate). Other names in common use include citrase, citratase, citritase, citridesmolase, citrate aldolase, citric aldolase, citrate lyase, citrate oxaloacetate-lyase, and citrate oxaloacetate-lyase
pro-3S)-CH2COO-->acetate''. This enzyme participates in
citrate cycle and
two-component system - general.
Structural studies
As of late 2007, 4
structures have been solved for this class of enzymes, with
PDB accession codes , , , and .
References
*
*
EC 4.1.3
Enzymes of known structure
{{4.1-enzyme-stub