Cilazapril is an
angiotensin-converting enzyme inhibitor (
ACE inhibitor
Angiotensin-converting-enzyme inhibitors (ACE inhibitors) are a class of medication used primarily for the treatment of hypertension, high blood pressure and heart failure. They work by causing relaxation of blood vessels as well as a decrease i ...
) used for the treatment of
hypertension
Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated. High blood pressure usually does not cause symptoms. Long-term high bl ...
and
congestive heart failure
Heart failure (HF), also known as congestive heart failure (CHF), is a syndrome, a group of signs and symptoms caused by an impairment of the heart's blood pumping function. Symptoms typically include shortness of breath, excessive fatigue, a ...
.
It was patented in 1982 and approved for medical use in 1990.
Chemistry
Of the eight possible
stereoisomers
In stereochemistry, stereoisomerism, or spatial isomerism, is a form of isomerism in which molecules have the same molecular formula and sequence of bonded atoms (constitution), but differ in the three-dimensional orientations of their atoms in ...
, only the all-(''S'')-form is medically viable.
Brand names
It is branded as Dynorm, Inhibace, Vascace and many other names in various countries. None of these are available in the United States as of May 2010.
[Cilazapril]
. '' Drugs.com''. Retrieved 28 May 2010.
References
ACE inhibitors
Carboxylic acids
Enantiopure drugs
Hoffmann-La Roche brands
Ethyl esters
Lactams
Prodrugs
Nitrogen heterocycles
Heterocyclic compounds with 2 rings
Carboxylate esters
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