Ciclotizolam
[DE Patent 2445430] (WE-973) is a drug which is a
thienotriazolodiazepine
A thienotriazolodiazepine is a heterocyclic compound containing a diazepine ring fused to thiophene and triazole rings. Thienotriazolodiazepine forms the central core of several pharmaceutical drugs including:
* Brotizolam
* Ciclotizolam
* De ...
derivative. It is a
partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may also be considered ligands which display both agonistic and antagonis ...
for the benzodiazepine site of the
GABAA receptor
Receptor may refer to:
* Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse
*Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...
, with similar
binding affinity
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. The etymology stems from ''ligare'', which means 'to bind'. In protein-ligand binding, the ligand is usually a m ...
to related compounds like
brotizolam, but a low
efficacy.
See also
*
Benzodiazepine
References
Chloroarenes
GABAA receptor positive allosteric modulators
Bromoarenes
Thienotriazolodiazepines
Cyclohexyl compounds
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