In molecular biology, cia-dependent small RNAs (csRNAs) are
small RNA
Small RNA (sRNA) are polymeric RNA molecules that are less than 200 nucleotides in length, and are usually non-coding
Non-coding DNA (ncDNA) sequences are components of an organism's DNA that do not encode protein sequences. Some non-coding DNA ...
s produced by ''
Streptococci''. These
RNAs
The Royal Naval Air Service (RNAS) was the air arm of the Royal Navy, under the direction of the Admiralty's Air Department, and existed formally from 1 July 1914 to 1 April 1918, when it was merged with the British Army's Royal Flying Corps t ...
are part of the
regulon
In molecular genetics, a regulon is a group of genes that are regulated as a unit, generally controlled by the same regulatory gene that expresses a protein acting as a repressor or activator. This terminology is generally, although not exclusiv ...
of the CiaRH
two-component regulatory system
In the field of molecular biology, a two-component regulatory system serves as a basic stimulus-response coupling mechanism to allow organisms to sense and respond to changes in many different environmental conditions. Two-component systems t ...
.
Two of these RNAs, csRNA4 and csRNA5, have been shown to affect
stationary-phase autolysis.
See also
*
Bacterial small RNA Bacterial small RNAs (bsRNA) are small RNAs produced by bacteria; they are 50- to 500-nucleotide non-coding RNA molecules, highly structured and containing several stem-loops. Numerous sRNAs have been identified using both computational analysis and ...
References
{{reflist, refs=
[{{cite journal, last=Halfmann, first=A, author2=Kovács, M , author3=Hakenbeck, R , author4= Brückner, R , title=Identification of the genes directly controlled by the response regulator CiaR in Streptococcus pneumoniae: five out of 15 promoters drive expression of small non-coding RNAs., journal=Molecular Microbiology, date=October 2007, volume=66, issue=1, pages=110–126, pmid=17725562, doi=10.1111/j.1365-2958.2007.05900.x, doi-access=free]
[{{cite journal, last=Marx, first=P, author2=Nuhn, M , author3=Kovács, M , author4=Hakenbeck, R , author5= Brückner, R , title=Identification of genes for small non-coding RNAs that belong to the regulon of the two-component regulatory system CiaRH in Streptococcus., journal=BMC Genomics, date=Nov 24, 2010, volume=11, pages=661, pmid=21106082, doi=10.1186/1471-2164-11-661, pmc=3091779]
RNA
Non-coding RNA