Christian Pike is a professor at the

Leonard Davis School of Gerontology The USC Leonard Davis School of Gerontology is one of the seventeen academic divisions of the University of Southern California in Los Angeles, focusing in undergraduate and graduate programs in gerontology, History Founded in 1975, the Leon ...

and a member of the USC Neuroscience Program. His ongoing work focuses on

Alzheimer's disease Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term me ...

and other age-related

neurodegenerative disorder A neurodegenerative disease is caused by the progressive loss of structure or function of neurons, in the process known as neurodegeneration. Such neuronal damage may ultimately involve cell death. Neurodegenerative diseases include amyotrophic ...

s. His laboratory studies the role of neuronal

apoptosis Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes incl ...

in neural diseases. Recently, his research found new use for synthetic

estrogen Estrogen or oestrogen is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three major endogenous estrogens that have estrogenic hormonal acti ...

s in lessening the effects of

Hormone Replacement Therapy Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. These symptoms can include hot flashes, vaginal ...

for Alzheimer's patients.

Honors and awards

*Turken Award from the

Alzheimer's Association The Alzheimer's Association was founded by Jerome H. Stone with the help of several family members in Chicago, Illinois, and incorporated on April 10, 1980, as the Alzheimer's Disease and Related Disorders Association, Inc. It is a non-profit Ame ...

*Trainee,

National Institute of Mental Health The National Institute of Mental Health (NIMH) is one of 27 institutes and centers that make up the National Institutes of Health (NIH). The NIH, in turn, is an agency of the United States Department of Health and Human Services and is the prima ...

Predoctoral Training Grant *Fellow, John Douglas French Alzheimer's Foundation *Andrus Center Associates, Small Grant Award *Hanson Family Trust Assistant Professor of Gerontology *USC Mellon Mentoring Award (Graduate Students) *Barron AM, Brown MA, Morgan TE, and Pike CJ (2015) Impact of continuous versus discontinuous progesterone on estradiol regulation of neuronal viability and sprouting following entorhinal cortex lesion in female rats.

Endocrinology (journal) ''Endocrinology'' is a peer-reviewed scientific journal published by The Endocrine Society. It is the Society's oldest journal and was established in 1917. It covers research on all aspects of endocrinology, including growth factors, steroids, t ...

156 (3): 1091–1099. *Yin F, Yao J, Sancheti H, Feng T, Melcangi RC, Morgan TE, Finch CE, Pike CJ, Mack WJ, Cardenas E, and Brinton RD (2015) Perienopause is a bioenergetic transition of female brain characterized by deficits in glucose metabolism and synaptic function.

Neurobiology of Aging ''Neurobiology of Aging'' is a peer-reviewed monthly scientific journal published by Elsevier. The editor-in-chief is Peter R. Rapp. ''Neurobiology of Aging'' publishes research in which the primary emphasis addresses the mechanisms of nervous ...

36 (7): 2282–2295. doi: 10.1016/j.neurobiolaging.2015.03.013. *Christensen A and Pike CJ (2015) Menopause, obesity and inflammation: Interactive risk factors for Alzheimer's disease.

Frontiers in Aging Neuroscience Frontiers Media SA is a publisher of peer-reviewed, open access, scientific journals currently active in science, technology, and medicine. It was founded in 2007 by Kamila and Henry Markram, and has since expanded to other academic fields. Fro ...

. 7: 130. doi: 10.3389/fnagi.2015.00130 *Moser VA and Pike CJ (2015) Obesity and sex interact in the regulation Alzheimer's disease. Neuroscience & Behavioral Reviews. In press. *Cacciottolo M, Christensen A, Moser VA, Liu J, Pike CJ, Morgan TE, Dolzhenko E, Charidimou A, Wahlund L-O, Wilberg K, Chiang GC-Y and Finch CE (in revision) Sex and APOE alleles in the microbleeds and Alzheimer's disease of mice and men. Neurobiology of Aging.

Patents

Compositions and Methods for the Treatment of Alzheimer's Disease. Filed: May 13, 2013; U.S. Patent Application No. 61/823,872 Inventors: Christian J. Pike, Anna M. Barron

Professional Activities: Memberships

Member,

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...

, 1989-1996 Member,

Society for Neuroscience The Society for Neuroscience (SfN) is a professional society, headquartered in Washington, DC, for basic scientists and physicians around the world whose research is focused on the study of the brain and nervous system. It is especially well kn ...

, 1991–Present Member,

International Society for Neurochemistry The International Society for Neurochemistry (ISN) is a professional society for neurochemists and neuroscientists throughout the world. History The idea of an organization like the ISN began in the mid-1950s as scientists began to devote more att ...

, 1998-2009 Member,

Endocrine Society The Endocrine Society is a professional, international medical organization in the field of endocrinology and metabolism, founded in 1916 as The Association for the Study of Internal Secretions. The official name of the organization was changed ...

, 2014–Present

References

External links

University of Southern California Davis School of Gerontology2015 Mellon Mentoring Awardee
Living people Year of birth missing (living people) {{Improve categories, date=July 2022