Choline-phosphate cytidylyltransferase () is an
enzyme that
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction
:CTP + choline phosphate
diphosphate + CDP-choline
where the two
substrates of this enzyme are
CTP and
choline phosphate, and the two
products are
diphosphate and
CDP-choline
Citicoline (International Nonproprietary Name, INN), also known as cytidine diphosphate-choline (CDP-Choline) or cytidine 5'-diphosphocholine is an intermediate in the generation of phosphatidylcholine from choline, a common biochemical process in ...
. It is responsible for regulating phosphatidylcholine content in membranes.
This enzyme belongs to the family of
transferases, specifically those transferring phosphorus-containing
nucleotide groups (
nucleotidyltransferases). The
systematic name of this enzyme class is CTP:choline-phosphate cytidylyltransferase. Other names in common use include phosphorylcholine transferase, CDP-choline pyrophosphorylase, CDP-choline synthetase, choline phosphate cytidylyltransferase, CTP-phosphocholine cytidylyltransferase, CTP:phosphorylcholine cytidylyltransferase, cytidine diphosphocholine pyrophosphorylase, phosphocholine cytidylyltransferase, phosphorylcholine cytidylyltransferase, and phosphorylcholine:CTP cytidylyltransferase. This enzyme participates in
aminophosphonate metabolism Aminophosphonates are organophosphorus compounds with the formula (RO)2P(O)CR'2NR"2. These compounds are structural analogues of amino acids in which a carboxylic moiety is replaced by phosphonic acid or related groups. Acting as antagonists of a ...
and
glycerophospholipid metabolism.
Structural studies
As of late 2007, two
structures have been solved for this class of enzymes, with
PDB accession codes and .
References
*
*
*
EC 2.7.7
Enzymes of known structure
{{2.7-enzyme-stub