Cholate—CoA ligase (, ''BAL'', ''bile acid CoA ligase'', ''bile acid coenzyme A ligase'', ''choloyl-CoA synthetase'', ''choloyl coenzyme A synthetase'', ''cholic thiokinase'', ''cholate thiokinase'', ''cholic acid:CoA ligase'', ''3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase'', ''3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase'', ''3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase'', ''THCA-CoA ligase'', ''3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate—CoA ligase'', ''3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)'', ''cholyl-CoA synthetase'', ''trihydroxycoprostanoyl-CoA synthetase'') is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
with
systematic name ''cholate:CoA ligase (AMP-forming)''.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...
: (1) ATP +
cholate
Cholic acid, also known as 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid is a primary bile acid that is insoluble in water (soluble in alcohol and acetic acid), it is a white crystalline substance. Salts of cholic acid are called cholates. Chol ...
+ CoA
AMP +
diphosphate + choloyl-CoA
: (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA
AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
This enzyme requires Mg
2+ for activity.
References
External links
*
{{DEFAULTSORT:Cholate-CoA ligase
EC 6.2.1