Chi-Chao Chan
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Chi-Chao Chan is a Chinese-born American
ophthalmologist Ophthalmology ( ) is a surgery, surgical subspecialty within medicine that deals with the diagnosis and treatment of eye disorders. An ophthalmologist is a physician who undergoes subspecialty training in medical and surgical eye care. Followin ...
and physician-scientist specialized in the diagnosis and pathology of eye diseases. She joined the National Eye Institute (NEI) as a postdoctoral researcher in 1982 and remained until her retirement in 2015. Chan was promoted in 1999 to senior investigator and chief of the NEI immunopathology section and the
histopathology Histopathology (compound of three Greek words: ''histos'' "tissue", πάθος ''pathos'' "suffering", and -λογία '' -logia'' "study of") refers to the microscopic examination of tissue in order to study the manifestations of disease. Spe ...
core.


Education

Chan completed a M.D. at Chung Shan Medical College (
Sun Yat-sen University of Medical Sciences The former Sun Yat-sen University of Medical Sciences (SUMS; ) was located in Yuexiu District, Guangzhou, Guangdong, China. - The address traces to "74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, Guangdong Province, China" It is government ...
) in 1967 just as the
Cultural Revolution The Cultural Revolution, formally known as the Great Proletarian Cultural Revolution, was a sociopolitical movement in the People's Republic of China (PRC) launched by Mao Zedong in 1966, and lasting until his death in 1976. Its stated goal ...
was commencing. She came to the U.S. via
Hong Kong Hong Kong ( (US) or (UK); , ), officially the Hong Kong Special Administrative Region of the People's Republic of China ( abbr. Hong Kong SAR or HKSAR), is a city and special administrative region of China on the eastern Pearl River Delt ...
in 1968. Chan learned English at
Boston University Boston University (BU) is a private research university in Boston, Massachusetts. The university is nonsectarian, but has a historical affiliation with the United Methodist Church. It was founded in 1839 by Methodists with its original campu ...
and took undergraduate courses at
Kent State University Kent State University (KSU) is a public research university in Kent, Ohio. The university also includes seven regional campuses in Northeast Ohio and additional facilities in the region and internationally. Regional campuses are located in As ...
and
Johns Hopkins University Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hem ...
. She earned a B.A. (1972) and a second M.D. (1975) at Johns Hopkins. Chan completed a residency in ophthalmology at
Stanford University Medical Center Stanford University Medical Center is a medical complex which includes Stanford Health Care and Stanford Children's Health. It is consistently ranked as one of the best hospitals in the United States and serves as a teaching hospital for the ...
from 1976 to 1979. She did a postdoctoral fellowship in
ophthalmic pathology Ophthalmic pathology is the subspecialty of surgical pathology and also a subspecialty of ophthalmology which deals with the diagnosis and characterization of neoplastic and non-neoplastic diseases of the eyes. Ophthalmic pathologists generally work ...
under at the
Wilmer Ophthalmological Institute The Wilmer Ophthalmological Institute, also referred to as the Wilmer Eye Institute, is a component of the Johns Hopkins University School of Medicine. Ophthalmologist William Holland Wilmer opened the Wilmer Eye Institute in 1925. Its home was c ...
from 1979 to 1982. Chan joined the National Eye Institute (NEI) from 1982 to 1986 for a second postdoctoral fellowship in clinical ocular immunology/uveitis in the laboratory of .


Career

Following her postdoctoral fellowship at the NEI, Chan continued working there as a medical officer. She was promoted in 1992 to chief of the immunopathology section. Chan became chief of the NEI histopathology core in 1999. Her laboratory had a strong relationship with the National Institutes of Health Clinical Center. The core, which had a Clinical Laboratory Improvement Approved (CLIA) certification, received both clinical and experimental specimens, and processes 6000-8000 samples annually. Chan was a mentor to NEI clinical and research post-doctoral and post-baccalaureate fellows. She has helped in the development and improvement of ophthalmology and vision research in China and, in this process, has promoted exchange among ophthalmologists and vision researchers within China, the United States, and the world. Chan coauthored over 600 publications. Chan's research led to new ways of diagnosing primary vitreoretinal lymphoma (PVRL). Her team discovered that certain changes at the protein and molecular level could be used to help diagnose PVRL earlier, enabling patients to start
chemotherapy Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemotherap ...
sooner. She also researched the pathology of uveitis and Von Hippel–Lindau disease and the genetics and pathogenesis of age-related
macular degeneration Macular degeneration, also known as age-related macular degeneration (AMD or ARMD), is a medical condition which may result in blurred or no vision in the center of the visual field. Early on there are often no symptoms. Over time, however, som ...
. Chan received recognitions including the 2010 outstanding achievement award in ophthalmology and visual science for
overseas Chinese Overseas Chinese () refers to people of Chinese birth or ethnicity who reside outside Mainland China, Hong Kong, Macau, and Taiwan. As of 2011, there were over 40.3 million overseas Chinese. Terminology () or ''Hoan-kheh'' () in Hokkien, refe ...
from the Chinese Ophthalmological Society, a gold fellow appointment from the
Association for Research in Vision and Ophthalmology The Association for Research in Vision and Ophthalmology (abbreviated ARVO) is an American learned society dedicated to ophthalmology and other vision-related topics. As of 2019, it has almost 12,000 members from 75 different countries. It was est ...
in 2011, and the 2013 senior achievement award of the
American Academy of Ophthalmology The American Academy of Ophthalmology (Academy) is a professional medical association of ophthalmologists. It is headquartered in San Francisco, California. Its membership of 32,000 medical doctors includes more than 90 percent of practicing ...
. Chan retired in 2015 after 33 years at the NEI. She continued as a scientist emeritus.


Personal life

Upon retirement, Chan relocated to
San Francisco San Francisco (; Spanish language, Spanish for "Francis of Assisi, Saint Francis"), officially the City and County of San Francisco, is the commercial, financial, and cultural center of Northern California. The city proper is the List of Ca ...
to live near her son and grandchildren.


References

{{DEFAULTSORT:Chan, Chi-Chao Living people Year of birth missing (living people) Place of birth missing (living people) People's Republic of China emigrants to the United States Sun Yat-sen University alumni Johns Hopkins School of Medicine alumni American ophthalmologists Women ophthalmologists National Institutes of Health people Physician-scientists Chinese ophthalmologists 20th-century American women physicians 20th-century American physicians 20th-century Chinese women scientists 20th-century Chinese physicians Chinese medical researchers American medical researchers American women medical researchers 21st-century American women physicians 21st-century American physicians